心理应激雌性大鼠海马-下丘脑-垂体雌激素受体的变化  

Change of estrogen receptor in hippocampus, hypothalamus and pituitary of female rats exposed to psychological stress

作　　者：柯江维[1] 王建红[2] 段荣[1] 

机构地区：[1]江西省儿童医院,江西南昌330006 [2]江西中医学院,江西南昌330006

出　　处：《中国病理生理杂志》2006年第1期98-101,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.39960026)

摘　　要：目的:探讨雌性大鼠心理应激状态下,海马-下丘脑-垂体雌激素受体(ER)的改变,进而阐明卵巢内分泌功能失调的机制。方法:采用声-光-电复合刺激作为心理应激制造大鼠卵巢内分泌功能失调模型;采用免疫组化方法和图像分析仪定量分析海马-下丘脑-垂体ER的表达。结果:采用声-光-电复合刺激雌性大鼠后,大鼠海马-下丘脑-垂体ER的表达下降。结论:心理应激雌性大鼠海马-下丘脑-垂体ER下降可能是卵巢内分泌功能失调的机制之一。AIM： To investigate the change of estrogen receptor （ER） in hippocampus, hypothalamus and pituitary of female rats exposed to psychological stress, and to illuminate the mechanism of dysfunction on ovarian reproductive endocrine function. METHODS： Sound, light and electricity were combined into a psychological stressful stimulus to induce female rat dysfunction on ovarian reproductive endocrine function. Immunohistochemical technique and image analysis were used to assess the expression levels of ER in hippocampus, hypothalamus and pituitary. RESULTS： When exposed to compound stressful stimulus of sound, light and electricity for 20 days in female rats, the expression levels of ER in hippocampus, hypothalamus and pituitary dropped. CONCLUSION： The decrease in estrogen receptor expression in hippocampus, hypothalamus and pituitary of female rats exposed to psychological stress may be one of the mechanisms of ovarian reproductive endocrine dysfunction.

关 键 词：应激 海马-下丘脑-垂体 受体 雌激素 免疫组织化学 

分 类 号：R363[医药卫生—病理学]