永生化人成牙本质细胞样细胞系的生物学特征  

The biological characters of immortal human odontoblast-like cell line

作　　者：王捍国[1] 肖明振[1] 赵守亮[1] 郝建军[1] 余擎[1] 

机构地区：[1]第四军医大学口腔医学院,西安710032

出　　处：《现代口腔医学杂志》2006年第1期38-40,共3页Journal of Modern Stomatology

基　　金：国家自然科学基金资助项目(编号:39970792;30270374);国家教育部回国人员启动基金资助项目(编号:2000HG003);第四军医大学学术新人资助基金资助项目(2003年)

摘　　要：目的明确永生化人成牙本质细胞样细胞系hTERT-hOd-l的生物学特征。方法在连续体外培养过程中,观察细胞的形态学特征和生长增殖特征并与人成牙本质细胞样细胞比较。结果细胞形态为成纤维细胞样,细胞器发达,生长增殖活跃,具有克隆形成能力。结论hTERT-hOd-l保持了人成牙本质细胞样细胞的生物学特征。Objective To explicate the biological characters of an immortal human odontoblast-like cell line hTERT-hod-1. Methods The morphology, growth and proliferation of the cells were observed during continuous culture in vitro and compared with that of human odontoblast-like cells, Results The hTERT-hod-1 cells showed fibroblast-like feature with rich in organelle. They grew and proliferated well and were able to form cell clone in vitro . Conclusion The hTERT-hOd-1 remains the biological characters of human odontoblast-like cells.

关 键 词：成牙本质细胞 生物学 细胞系 

分 类 号：R78[医药卫生—口腔医学]