婴幼儿血管瘤iNOS的表达及其与血管内皮细胞增殖能力的关系  

Relationship between expression of inducible nitric oxide synthase and proliferative potency of endothelium in hemangioma in infants

作　　者：李劲松[1] 李海刚[2] 陈伟良[1] 何璇凌[1] 杨朝晖[1] 程慧琳[1] 

机构地区：[1]中山大学附属第二医院口腔颌面外科,广州510120 [2]中山大学附属第二医院病理科,广州510120

出　　处：《中华整形外科杂志》2006年第1期49-51,共3页Chinese Journal of Plastic Surgery

基　　金：广东省自然科学基金(04009342);广东省医学科研基金(A2004196)资助

摘　　要：目的研究婴幼儿血管瘤组织中诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)的表达,及其与血管内皮细胞增殖能力的关系。方法收集我院2001年1月至2002年5月手术切除的49例血管瘤和29例血管畸形石蜡标本,利用免疫组织化学染色检测其iNOS和Ki-67蛋白的表达。结果49例血管瘤组织中iNOS蛋白的阳性率和Ki-67蛋白的阳性表达指数分别为38%和(10.98±7.93)%,均分别显著高于29例血管畸形组织中的3%和(0.03±0.19)%。增生期血管瘤组Ki-67蛋白的阳性表达指数为(12.67±7.65)%,显著高于消退期血管瘤组的(7.27±7.49)%(P=0.028)。无论是全部78例血管病变还是49例血管瘤,iNOS阳性组的Ki-67蛋白的阳性表达指数均显著高于iNOS阴性组(P<0.05)。结论血管瘤组织中iNOS和Ki-67蛋白的表达均高于血管畸形,而且血管瘤中血管内皮细胞的增殖能力可能与其iNOS阳性率的增高有关。Objective To investigate relationship between expression of inducible nitric oxide synthase （iNOS） and proliferative potency of endothelium in hemangioma（HM）.Methods Immunohistochemical staining was used to detect expression of iNOS and Ki-67 protein in 49 cases of HM and 29 cases of vascular malformation （VM） . Results Expressive rate of iNOS and Ki-67 protein of 49 cases of HM was 38% and （ 10.98 ± 7.93）% . Expressive rate of iNOS and Ki-67 protein of 29 cases of VM was respectively 3% and （0.03 ± 0.19） %. The expressive rate of iNOS and Ki-67 protein of HM was significantly higher than that of VM （P = 0.001 and 0）. The expressive rate of Ki-67 protein of HM of proliferative phase was （12.67 ± 7.65）%, which was significantly higher than that of HM of extinctive phase, （7.27 ± 7.49）% （P = 0.028）. Conclusions Expression of iNOS and Ki-67 protein of HM is significantly higher than that of VM, and the proliferative potency of HM is significantly higher than that of VM.

关 键 词：血管瘤 血管畸形 一氧化氮合酶 细胞增殖 

分 类 号：R732.2[医药卫生—肿瘤]