Midkine在食管鳞癌中的表达及其与微血管密度的关系  

Expression and Significance of Midkine(MK)in Esophageal Squamous Cell Carcinoma and Correlation with Microvessel Density

作　　者：王琼[1] 赵永年[1] 刘钧[1] 朱治键[1] 

机构地区：[1]川北医学院病理教研室,四川南充637000

出　　处：《肿瘤防治研究》2006年第1期15-16,共2页Cancer Research on Prevention and Treatment

基　　金：四川省教育厅青年基金资助课题(2003B012)

摘　　要：目的研究MK在食管鳞癌中的表达及与肿瘤血管形成的关系。方法采用免疫组织化学SP法检测45例食管鳞癌组织中MK的表达,同时以CD34标记微血管内皮细胞测定微血管密度(mi-crovessel density,MVD)。结果45例食管鳞癌组织中MK阳性表达率为77.8%,MK阳性的食管鳞癌组织MVD为40.43±6.27,MK阴性的食管鳞癌组织MVD为31.34±3.89,两者有显著性差异(P<0.01)。结论MK在食管鳞癌中高表达并与血管形成有关。Objective To study the expression of midkine in esophageal squamous cell carcinoma and the relation to angiogenesis. Methods A Immunohistochemical SP technique was used to detect the expression of MK in 45 cases who suffer from esophageal squamous cell carcinoma , Microvessel density（MVD） was also determined in endothelial as CD34. Results Positive MK Immunostaining was detected in 77. 8% of esophageal carcinoma,MVD was 40.43± 6.27 in esophageal carcinoma positive for MK while it was 31. 34±3.89 in esophageal carcinoma negative for MK （P〈0.01）. Conclusion Overexpression of Mk in esophageal carcinoma, and correlation with angiogenesis of esophageal carcinoma.

关 键 词：食管癌 MK 血管生成 

分 类 号：R735.1[医药卫生—肿瘤]