沙棘籽油对小鼠实验性肝硬化的保护作用及参数分析  

The protection role and parameter analysis of seed oil of hippophae rhamnoides L.on experimental hepatocirrhosis in mice

作　　者：施彦[1] 徐婧[2] 刘超[2] 叶存奇[2] 黄成[2] 

机构地区：[1]南京大学医学院,江苏南京210093 [2]南京大学生命科学学院,江苏南京210093

出　　处：《医学研究生学报》2006年第1期40-42,共3页Journal of Medical Postgraduates

基　　金：南京大学创建世界高水平大学学生创新工程基金资助项目(批准号:C-2004SKY-011)

摘　　要：目的:研究沙棘籽油(seed oil of h ippophae rhamnoides L.)对实验性小鼠肝硬化的影响。方法:采用四氯化碳(CC l4)导致小鼠肝硬化,分别饲以不同浓度的沙棘籽油,饲养45 d后分别检测小鼠血清谷丙转氨酶(GPT)和超氧化物歧化酶(SOD)及肝组织的SOD活力和丙二醛(MDA)含量的变化,观察沙棘籽油对小鼠肝的保护作用,并以GPT生化指标值为应变量,以沙棘籽油剂量为自变量,建立量效曲线。结果:沙棘籽油能明显对抗血清中GPT的升高,而且对调节SOD活力的下降及MDA的升高也有较明显效果。沙棘籽油剂量对GPT下降的函数相关性较好。结论:沙棘籽油对小鼠实验性肝硬化具有一定的保护作用。Objective ： To study the effect of seed oil of Hippophae rhamnoides L. （SOHR） on experimental hepatocirrhosis in mice. Methods ： CC14 was used in the experiment to form the model of experimental hepatocirrhosis in mice. In order to measure the possible changes of GPT and SOD in serum and SOD and MDA in tissues, we fed these mice with different concentration of SOHR for 45 days. The DoesEffect Curve was set up based on the data of this experiment. Results： SOHR could control the increase of GPT in serum and the decrease of SOD evidently, as well as the increase of MDA in tissues. The relationship of that the Hippophae rhamnoides dose with the decrease of GPT is significant. Conclusion： SOHR protects the experimental hepatacirrhosis in mice.

关 键 词：沙棘籽油 谷丙转氨酶 超氧化物歧化酶 丙二醛 量效曲线 

分 类 号：R575.2[医药卫生—消化系统]