非酒精性脂肪性肝病患者腰臀比测量的意义  

The significance of waist to hip ratio in nonalcoholic fatty liver disease

作　　者：魏双琴[1] 韩树堂[1] 

机构地区：[1]南京大学医学院附属鼓楼医院消化科,江苏南京210008

出　　处：《医学研究生学报》2006年第1期51-53,共3页Journal of Medical Postgraduates

基　　金：江苏省自然科学基金资助项目(批准号:BK2003009)

摘　　要：目的：研究非酒精性脂防性肝病（NAFLD）各危险因素中腰臀比（WHR）测量的意义。方法：对象来自本院体检中心，入选标准为体重指数（BMI）在25～29．9之间，无酗酒史，乙型肝炎病毒标志物阴性，无糖尿病史的患者。81例符合标准者中，59例患者为NAFLD组，22例健康人为对照组。结果：以性别、年龄、BMI、WHR、血清胆固醇、三酰甘油、胰岛素敏感指数为自变量，NAFLD为应变量，进行二价多元logistic回归分析显示，性别、年龄、MBI、胆固醇、三酰甘油对NAFLD的发病无影响。WHR和胰岛素敏感指数均为NAFLD的独立影响因素（P=0．01和P=0．069）。结论：在BMI匹配的轻度肥胖非糖尿病患者个体中，WHR是NAFLD的独立影响因子。Objective ： To evaluate the importance of waist to hip ratio among all the possible risk factors in the development of NAFLD. Methods： The samples were selected from individuals receiving physical examination from the 14th of October to the 4th of November in 2004. The enrolling criteria were as follows：①BMI between 25 -29.9.②ethanol consumption was less than 40 g per week. ③markers of hepatitis virus were negative. ④no diabetes mellitus. The diagnosis of fatty liver was based on sonographic evidence. According to the standards, 81 cases were chosen, including 59 patients with NAFLD and 22 normal controls. Seven indices were recorded in fasting state： age, BMI, waist to hip ratio（WHR） , serum cholesterol, serum lipid, serum glucose and insulin sensitivity index. Results： The fatty liver group, compared with the normal controls, was significantly marked with higher BMI （26.70 vs 26.15, P=0. 026） , WHR（0.90 vs 0. 86, P =0. 002） , serum lipid（ 1.99 vs 1.42 P =0. 001 ） and lower insulin sensitive index（0. 025 vs 0. 039, P = 0. 005 ）. By binary logistic regression analysis, WHR and insulin sensitive index is significantly associated with the development of NAFLD, and the P value is 0.01 and 0. 069 respectively. Conclusion ： WHR is an independent factor in the development of NAFLD in patients with BMI matched and non - DM mild fatty individuals .

关 键 词：内脏型肥胖 非酒精性脂防性肝病 体重指数 腰臀比 

分 类 号：R575.5[医药卫生—消化系统]