垂体腺瘤MRI强化特征与VEGF、bFGF mRNA表达的关系  

Correlation between Contrast-enhanced MRI Features and the mRNA Expression of VEGF and bFGF in Pituitary Adenomas

作　　者：刘凡[1] 王小宜[1] 廖伟华[1] 王润文[1] 谭运年[2] 

机构地区：[1]中南大学湘雅医院放射科,湖南长沙410008 [2]中南大学肿瘤研究所

出　　处：《实用放射学杂志》2006年第1期9-12,共4页Journal of Practical Radiology

基　　金：国家自然科学基金资助项目(基金编号30370433)

摘　　要：目的探讨垂体腺瘤T1W I动态增强及常规MR I表现与VEGF和bFGF mRNA表达的相关性。方法对30例垂体腺瘤患者术前行快速梯度回波序列(Turbo-FLASH)T1W I动态增强和常规MR I,术后应用逆转录PCR(RT-PCR)方法检测垂体腺瘤组织标本中VEGF和bFGF mRNA的表达,分析动态增强及常规MR I表现与VEGF和bFGF mRNA表达之间的关系。结果垂体腺瘤动态增强时间-信号强度曲线(SI-TC)不同类型之间的VEGF、bFGF mRNA值有显著性差异(Ρ<0.05)。VEGF和bFGF与SSm ax呈显著正相关(Ρ<0.05)。肿瘤强化率不同程度间的VEGF、bFGF值有显著性差异(Ρ<0.05)。结论垂体腺瘤MR I强化特征可一定程度反映VEGF和bFGF mRNA的表达。Objective To investigate the correlation between mRNA expression of VEGF , bFGF and dynamic contrast - enhanced T1 - weighted MRI together with conventional MRI features in pituitary adenomas. Methods Conventional MRI and gadolinium-enhanced dynamic Turbo-FLASH imaging was performed preoperatively in 30 patients with histologically verified pituitary adenoms. VEGF and bFGF mRNA expression were determined in pituitary adenomas by using comparative reverse transcription-polymerase chain reaction （RT-PCR） in all patients. The correlation between mRNA expression of VEGF/bFGF and dynamic contrast-enhanced and conventional MRI feature.s were studied . Results Significant difference in VEGF and bFGF mRNA expression was found among pituitary adenomas according to different signal intensity-time curve （ SI-TC ） type （P 〈 0.05 ） . SSmax positively correlated well with VEGF and bFGF mRNA expression （P〈0.05）. Tumor-associated degree of contrast enhancement became serious with VEGF and bFGF mRNA expression up-regulating （P〈0. 05）. Conclusion Contrast-enhanced MRI features may be valuable tools in evaluating pituitary tumor angiogenesis.

关 键 词：垂体腺瘤 磁共振成像 动态增强 血管生成 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]