COX-2和VEGF表达及其与胆管癌的相关性研究  

Correlation of Between Expressions of COX-2 and VEGF in Cholangiocarcinama

作　　者：郜朝霞[1] 孙权[1] 

机构地区：[1]武汉大学中南医院普外科,武汉430071

出　　处：《武汉大学学报（医学版）》2006年第1期38-41,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨环氧合酶-2(COX-2)和血管内皮生长因子(VEGF)在胆管癌组织中的表达及其与胆管癌发生、发展及转移的关系。方法:运用免疫组织化学SP法研究COX-2和VEGF相关抗原在胆管癌组织中的表达。结果:43例胆管癌组织中COX-2和VEGF的表达阳性率分别为81.40%和76.74%,而二者在9例胆管结石病人的组织中均未见阳性表达;COX-2表达阳性率在胆管癌高、中分化组明显高于低分化组,转移阳性组明显高于转移阴性组,其差异均有显著性意义(P<0.05);VEGF的表达阳性率在胆管癌转移组明显高于未转移组,其差异有显著性意义(P<0.05);COX-2表达与VEGF表达呈正相关(r=0.727,P<0.01)。结论:COX-2和VEGF可能在胆管癌的发生、发展及转移过程中起着关键性作用,二者在血管生成过程中密切相关。To investigate the expression of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor（VEGF） in human cholangiocarcinoma and their correlation with clinicobiological behavior. Methods： Expressions of COX-2 and VEGF in 43 cases of human cholangiocarcinoma were detected with immunohistochemistry of SP. Resultsz Expression rates of COX-2 and VEGF in cholangiocarcinoma were 81.40% and 76.74%, respectively. No expression of COX-2 and VEGF in caculus of bile duct was detected. The positive rate of COX-2 was significantly higher in well-differentiated and moderately-differentiated or metastatic tumors than in poorly-differentiated or non-metastatic tumors. The positive rate of VEGF was significantly higher in metastatic tumors than in non-metastatic tumors. Conclusion： COX-2 and VEGF may play a crucial role in tumorigenesis, tumor progression and metastasis in cholangiocarcimoma and both may have close relation in the angiogenesis.

关 键 词：胆管癌 环氧合酶-2 血管内皮生长因子 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]