CD15s与P-选择素在宫颈鳞状细胞癌的表达和意义  

Expression of CD15s Antigen and P-selectin in Cervical Squamous Cell Carcinoma

作　　者：袁建寰[1] 林静吟[2] 夏婷[3] 颜琳[3] 陈惠祯[3] 

机构地区：[1]武汉大学医学院,武汉430071 [2]广东省惠州市中心人民医院妇产科,惠州516001 [3]武汉大学中南医院妇瘤科,武汉430071

出　　处：《武汉大学学报（医学版）》2006年第1期44-46,103,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨CD15s抗原、P-选择素(P-selectin)是否与宫颈鳞癌的转移相关。方法:采用免疫组织化学染色技术分别检测了CD15s和P-选择素在56份宫颈鳞癌手术标本的表达,分析其表达水平与淋巴转移的相关性。结果:①在原发病灶中,有淋巴结转移的病例组CD15s的表达高于无转移组(P<0.01);而P-选择素在两组间的表达差异无显著性(P>0.05);②CD15s和P-选择素在癌转移的淋巴结的表达均高于宫颈病灶(P<0.05和P<0.01);CD15s在宫颈癌标本的表达显著高于正常宫颈组织(P<0.01),而P-选择素在两者间的表达差异无显著性(P>0.05)。结论:CD15s与宫颈鳞癌的转移潜能呈正相关,P-选择素与此无关;CD15s与P-选择素协同介导了宫颈鳞癌在淋巴结的粘附。Objective： To study whether CD15s antigen and P-selectin were associated with the metastasis of cervical squamous cell carcinoma （CSCC）. Methods： The expressions of CD15s and P-selectin in 56 cases of CSCC and 43 samples of normal cervix tissues were detected by immunohistochemical staining. Results： ① The expressions of CD15s and P-selectin in the metastasized lymph nodes were significantly higher than those in the original focus（P〈0.05 and P〈0.01, respectively）. ② In the original focus, the expression of CD15s in the group of metastasis was significantly higher than that in the group of nonmetastasis （P〈0.01）, but there was no statistic difference of the expression of P-selectin between the two groups （P〉0.05）. The expression of CD15s in the carcinoma focus was much higher than that in the normal cervix tissue （P〈0.01）, while no significant differences of the expression of P-selectin were found between these two kinds of samples （P〉0.05）. Conclusion： It is CD15s antigen, not the P-selectin, which activates the emigration of CSCC;CD15s and P-selectin play a mediate role for the CSCC to adhere to lymph nodes.

关 键 词：CD15S抗原 P-选择素 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]