Ames实验对叶黄素的致突变性与抗突变性研究  

Studies on the Safety and Antimutagenicity of Lutein

作　　者：王明臣[1] 张善锋[1] 毛红丽[2] 金国平[1] 董子明[1] 

机构地区：[1]郑州大学医学院生物化学与分子生物学教研室,河南郑州450052 [2]郑州大学一附院检验科,河南郑州450052

出　　处：《癌变．畸变．突变》2006年第1期65-67,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：背景与目的研究不同剂量的叶黄素致突变性、抗突变性及抗突变机理的初步分析。材料与方法采用Ames试验常规方法进行检测。结果1335μg/皿、668μg/皿、334μg/皿和167μg/皿剂量的叶黄素对TA97、TA98、TA100和TA102菌株在加与不加S9条件下均无致突变性;对TA98和TA100菌株具有显著的抗突变作用。结论在本实验条件下,叶黄素对Ames试验无致突变性,且有显著的抗突变作用,抗突变的机理为叶黄素具有综合的抗突变作用。BACKGROUND ＆ AIM： To study the effects of lutein on mutagenicity and antimutation anti-mutagenicity. MATERIAL AND METHODS： The studies were conducted with Ames test. RESULTS： In Ames test, the mutagenicity of Lutein group was no more than 2 times that of the control group. In test, comparing with positive group, Lutein groups could decrease the colonies in TAgs and TA100 strains. CONCLUSION： No mutagenicity was observed with lutein in this study .Moreover, we demonstrated that lutein possessed significant antimutagenic properties.

关 键 词：叶黄素 AMES试验 抗突变 

分 类 号：R114[医药卫生—卫生毒理学]