浅表性和浸润性膀胱癌微环境中树突状细胞的变化及意义  

Significance of Dendritic Cells Within and Adjacent to Transitional Cell Carcinoma of Bladder

作　　者：丘少鹏[1] 黄桂晓[1] 毛晓鹏[1] 王杜渐[1] 

机构地区：[1]中山大学附属第一医院泌尿外科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2006年第1期29-32,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金重点资助项目(021907)

摘　　要：目的研究树突状细胞(Dc)在不同类型膀胱移行细胞癌及癌旁组织中的变化以及与肿瘤病理分级的关系,探讨恶性肿瘤免疫逃避的可能机制。方法将133例膀胱移行细胞癌病理标本按WHO标准进行病理分级,按1987年国际抗癌协会(UICC)标准进行临床分型(浅表和浸润),应用免疫组化法检测病理标本中Dc。结果133例标本中肿瘤Dc数目明显少于瘤旁组织(G116.85±1.1,G29.45±2.17,G32.99±1.19vsG121.8±4.78,G221.71±4.72,G320.00±5.49,P<0.01)并随肿瘤病理分级的增加而减少,相同病理分级浅表性膀胱癌实质内Dc数目(G210.79±1.69;G34.79±0.67)明显多于浸润性膀胱癌实质内Dc数目(G27.52±1.0;G32.46±0.66),其差别具有统计学意义(P<0.01);肿瘤旁组织Dc数目在不同肿瘤病理分级、临床分型的标本中差别无统计学意义(P>0.05)。结论Dc仅在机体有炎症或肿瘤时作为抗原递呈者出现;肿瘤内Dc数目的减少是恶性肿瘤逃避机体的免疫监视和排斥的一个可能机制;浸润性膀胱癌容易转移可能与瘤内Dc数目及活性过度下调和Dc过早凋亡有关。[Objective] To study the relation between dendritic ceils （Dc） within and adjacent to transitional cell carcinoma （TCC） of bladder and the grades of cancer.[Methods] A total of 113 cases of pathologic specimens were classified by grades or by types according to the standards of WHO or Union Internationale Contre le Cancer （UICC）. Dc in specimens were detected by using immunohistochemical staining. [Results] The amounts of Dc in tumor were significantly lower than that in the tissue adjacent to the tumor （G116.85±1.1,G29.45±2.17,G2 2.99±1.19 vs G1 21.8±4.78,G2 21.71±4.72,G3 20.00±5.49, P〈 0.01）. In tumor of identical grades, the numbers of Dc in superficial cancer （G2 10.79±1.69; G34.79±0.67） were significantly higher than those in invasive cancer （G2 7.52± 1.0; G3 2.46±0.66, P〈 0.01）. There was no difference of the number of Dc in the tissue adjacent to tumor between grades （P 〉0.05）.[Conclusion] The amounts of Dc in tumor decreased with the grades rising. The decrease of the numbers of Dc is probably relevant to the invasion or escaping immune supervision.

关 键 词：树突状细胞 膀胱癌 移行细胞癌 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]