4—6岁儿童唾液免疫生化指标与龋病的关系  

Correlation between Immunochemical Level and Patient With Caries

作　　者：黄昊红[1] 于浩[1] 张琳[2] 刘泓[2] 牛玉梅[2] 王迺谦[2] 

机构地区：[1]齐齐哈尔医学院第二附属医院口腔科,黑龙江齐齐哈尔161006 [2]哈尔滨医科大学口腔医院口腔内科,黑龙江哈尔滨151000

出　　处：《华西口腔医学杂志》2006年第1期77-78,共2页West China Journal of Stomatology

基　　金：黑龙江省自然科学基金资助项目(D01-53)

摘　　要：目的探讨龋病患者唾液有关免疫生化指标与龋病的关系。方法收集4—6岁龋病患者、无龋者各45人,共90人,采用免疫放射法测定唾液中分泌型免疫球蛋白(ASIgA)的含量;用比浊法测定其溶菌酶(LZ)含量;用比色法测定其碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)的含量。测定结果用t检验进行分析。结果无龋人群、有龋人群LZ、ALP、SIgA含量的均数之间有显著性差异(P<0.05),无龋人群、有龋人群LDH之间无显著性差异(P>0.05)。结论龋病的发生可能与唾液的生化指标有关。Objective To explore the relationship between immunochemical level of salivary and caries in children aged 4-6 years old. Methods Two groups were assorted as patients with caries and without caries. Every group included 45 people. Measurements of salivary secretory immunoglobulin A （SIgA）were performed by using radio-immunoassay and single agar diffusion assay. The levels of lysozyme （LZ）, alkaline phosphatase （ALP）and lactic dehydrogenase （LDH）were studied with colorimetry and turbidimentry. Results The levels of LDH, SigA, ALP, LZ had significant difference between the two groups（P〈0.05）. The level of LDH between patients and peoples without caries had little difference （P〉0.05）. Conclusion The incidence of caries is associated with age, and it may have association with immunochemical levels of salivary.

关 键 词：龋病 唾液 免疫球蛋白 酶 

分 类 号：R788.1[医药卫生—口腔医学]