河南食管癌高发区食管癌高癌家族调查  

Epidemiological investigation on familial esophageal cancer from the subjects at high incidence area in Henan

作　　者：李琮宇[1] 李苹娟[1] 吴会芳[1] 郭涛[1] 张彦霞[1] 邵珊[1] 王苒[1] 常志伟[1] 王智卿[1] 杜芳[1] 余炜伟[1] 范宗民[1] 王立东[1] 

机构地区：[1]郑州大学医学实验中心癌症研究室河南省食管癌重点开放实验室郑州大学第一附属医院内科,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第1期32-34,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家杰出青年科学基金资助项目30025016;河南省高校创新人才工程基金资助项目1999125;河南省医学科技攻关基金资助项目20058;河南省食管癌重点开放实验室基金资助项目20050227;郑州大学211工程基金资助项目

摘　　要：目的:了解食管癌家族聚集性的流行状况。方法:采用统一问卷调查表,逐户调查。对河南省食管癌高发区448户1107人进行家系调查。结果:共收回264份问卷。264户中,有家族性食管癌共153户(58%)。直系三代中发生10例以上食管癌患者的家庭有5户(2%),7例患者的家庭有8户(3%),而三代中发生6例、5例、4例和3例食管癌的家庭分别为13户(5%)、21户(8%)、28户(11%)和46户(17%)。结论:河南食管癌高发区食管癌家族聚集性发生十分常见,提示遗传因素在食管癌变中可能起重要作用。Aim ： To further understand the prevalence of familial esophageal cancer （EC） and to establish familial esophageal cancer model through the epidemiological investigation on the subjects at the high-incidence area in Henan. Methods： Standard questionnaires were distributed to 1 107 subjects from 448 households. Results： The investigation on 264 households demonstrated that, within continuous three generations, there were 5 households （2%） with more than 10 EC patients; 8 households with 7 EC patients （3%） ; and the number of households with 6, 5,4 and 3 EC patients was 13 （5%） , 21 （8%） , 28（ 11% ） and 46（ 17% ） , respectively. Of the 264 households interviewed, there were 153 households （58%） with familial esophageal cancer history. Conclusion： The prevalence for familial EC in the high-incidence area forEC in Henan is high, which suggests that genetic changes may play an important role in EC.

关 键 词：食管癌 流行病学调查 高发区 

分 类 号：R735.1[医药卫生—肿瘤]