急性脑梗死动脉溶栓治疗时效分析  

Analysis of therapeutic time window and effect in acute cerebral infarction treated with intra-arterial thrombolytic therapy

作　　者：杨瑞民[1] 张铭秋[1] 赵东菊[1] 李奋保[1] 姚卫华[1] 赵鹏[1] 刘爱光[1] 

机构地区：[1]河南省卫辉市新乡医学院第一附属医院影像介入中心,河南卫辉453100

出　　处：《中国介入影像与治疗学》2006年第1期23-25,共3页Chinese Journal of Interventional Imaging and Therapy

基　　金：河南省教育厅科技攻关项目(20013200020)基金资助

摘　　要：目的 分析急性脑梗死患者不同时间的动脉内溶栓治疗效果，探讨影响治疗时间窗的因素。方法 54例脑梗死患者均在CT检查及血管造影基础上接受选择性动脉溶栓治疗，其中在6h以内溶栓者42例，6～24h溶栓者12例。术后统计两组患者的血管再通率和神经功能缺失积分差值。结果 两组患者冶疗有效率分别为88．1％和75．0％，显效率分别为71．4％和50．0％，血管再通率分别为69．0％和50．0％，血管再通中位时间分别为68和73min。结论 动脉内溶栓时间窗是与多种因素密切相关的，仅以发病时间不超过6h作为治疗标准是不够全面的，应当根据病情合理放宽溶栓的时间窗，最大降低患者的病残率，提高了患者的生活质量。Objective To analyze the effect and to discuss the factors that influence therapeutic time windows in acute cerebral infarction treated with intra-arterial thrombolytic therapy. Methods Fifty-four cases were examined by CT and an giography and received intra-arterial thombolytic therapy. Forty-two cases whose time from onset of stroke to beginning of thrombolysis were〈6 hours, i2 cases were 12-96 hours. Therecanalization rate and clinical outcome were statisticsed on two groups. Results The effectiveness rate of two groups was 88. 1% and 75.0% respectively, the excellence rate was 71. 4% and 50.0% respectively, the recanalization rate was 69.0% and 50.0% respectively, the reperfusive time of occluded artery was 68 and 73 minutes respectively. Conclusion The therapeutic time window was closely related to a lot of factors, it is not overall to be limited within 6 hours. Part of the cases with cerebral infarction after 6 hours of stroke onset can benefit from intra-arterial thrombolytic therapy.

关 键 词：脑梗死 动脉溶栓 时间窗 急性脑梗死 时效分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]