雌激素受体β基因多态性与血脂水平的研究  

Study on Correlation between ERβ Gene Polymorphism and Serum Lipid Level

作　　者：邵华[1] 李艳[1] 张平安[1] 李栋[1] 廖声荣[1] 

机构地区：[1]武汉大学人民医院检验科,邮政编码武汉430060

出　　处：《微循环学杂志》2006年第1期47-49,共3页Chinese Journal of Microcirculation

基　　金：湖北省自然科学基金资助项目(2000J070)

摘　　要：目的:探讨中国人群雌激素受体β(ERβ)基因多态性的分布情况及其与血脂水平的关系。方法:采用PCR-RFLP技术检测湖北地区131例正常人的ERβ基因RsaI和AluI酶切多态性,同时检测血脂水平。结果:分析ERβ基因RsaI和AluI两个酶切位点的基因多态性,分别以Rr型、aa型最多,而以RR型、AA型最少,其分布在男女组间无显著性差异(P>0.05)。ERβRsaI和AluI不同基因型间血清TC、TG、HDL-C、LDL-C、apoAI、apoB水平均有一定差异,但无统计学意义(P>0.05)。结论:ERβ基因RsaI和AluI酶切多态性可能不影响人群的血脂水平。Objective: In order to explore the correlation between estrogen receptor β (ERβ) gene polymorphism and serum lipid level in Chinese Han nationality. Method: 131 healthy controls were studied. PCR-RFLP tecnique were employed to determine ERβ gene polymorphism. Results: There were no statistically significant differences (P>0.05) in ERβ RsaI and AluI genotype frequencies between male and female.when the subjects were divided into 3 subgroups according to RsaI and AluI genotype,the differences among the subgroups were not statistically significant(P>0.05).Conclusion: ERβ RsaI and AluI gene polymorphism dose not have obvious influence on lipid metabolism.

关 键 词：雌激素受体Β 基因多态性 血脂水平 Receptor 类固醇激素受体 甲状腺激素受体 维生素D3受体 配体结合区 转录活性因子 家族成员 

分 类 号：R737.9[医药卫生—肿瘤] R541.4[医药卫生—临床医学]