氨磷汀在儿童肿瘤化疗中的应用  

Administration of Amifostine in Chemotherapy of Neoplasm in Children

作　　者：刘立真[1] 唐锁勤[1] 张晓飞[1] 黄东升[1] 王建文[1] 

机构地区：[1]中国人民解放军总医院儿内科,北京100853

出　　处：《实用儿科临床杂志》2006年第3期172-173,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的研究氨磷汀在儿童肿瘤化疗中的作用及不良反应。方法随机选择肿瘤32例患儿,采用自身对照,观察患儿在同一化疗方案中使用氨磷汀辅助治疗后黏膜损伤、骨髓抑制时间、发热持续时间、抗生素及刺激因子应用时间及氨磷汀的不良反应。结果氨磷汀辅助治疗组发生黏膜溃疡4例,明显低于对照组9例;中性粒细胞<0.5×109/L持续时间缩短,血小板<5×109/L持续时间缩短;发热持续时间、抗生素和刺激因子应用时间缩短。两组化疗过程中均未出现低体温、皮疹、低血压等情况,化疗后肾功能、心电图均正常;对肝功能影响程度相似;氨磷汀组低钙血症尤其是低钙性抽搐发生率高。结论氨磷汀能够有效保护正常组织细胞,不良反应较低,可在儿童肿瘤患者化疗中应用。Objective To assess the efficacy and safety of amifostine in chemotherapy of neoplasm in children. Methodls Auto - control study was conducted in 32 children to observe the damage of mucous membrane, the time of bone marrow depression, fever, the use of antibiotics and G-CSF malignant tumor treated with amifostine during chemotherapy. Results The damage of mucous membrane was lower in amifostine group compared with the control group（4/32 vs 9/32, P = 0. 027）. The duration of lower neutrophil （ 〈 0.5 × 10^9/L） and platelet （ 〈 5 × 10^9/L） were shortened in amifosntine group （7 ± 4 vs 11 ± 5, P = 0 ;3 ± 3 vs 7±5, P =0. 001 ）. The time of fever,the use of antibiotics,and G CSF were shortened in 32 children with malignant tumor treated with amifostine during chemotherapy（2 ± 3 vs 4 ± 3, P = 0,008 ; 5 ± 4 vs 8± 5, P = 0. 004 ; 7 ± 4 vs 9 ±5, P = 0. 031 ）, No significant difference in hypothermia, skin eruption or hypoterision was observed in 2 groups. The damage to the kidneys, liver and heart were similar in amifotine group and nonamifostine, More hycaemia, especially convubion were observed in amifostine group. Conclusion Amifostine, a drug of orotectinu normal tissue could be safely used in chemotherapy of neoplasnl in children.

关 键 词：氨磷汀 儿童 化学疗法 

分 类 号：R730.5[医药卫生—肿瘤]