mdm2基因在肾母细胞瘤中的表达及其与临床病理因素的关系  

Expression of mdm2 Genes in Nephroblastoma in Childhood and Its Relationship with Clinical Pathological Parameters

作　　者：魏华[1] 孔燕[1] 靳振怀[1] 陈淑敏[2] 丁勇[1] 

机构地区：[1]徐州医学院附属医院小儿外科,江苏徐州221002 [2]徐州医学院附属医院病理科,江苏徐州221002

出　　处：《实用儿科临床杂志》2006年第3期183-184,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨mdm2基因在小儿肾母细胞瘤中的表达及其与临床病理因素的关系。方法应用免疫组织化学技术检测24例肾母细胞瘤中的mdm2表达水平,分析mdm2与临床病理因素的关系。结果在24例肾母细胞瘤中mdm2的表达水平与淋巴结转移、临床分期及分化程度呈明显相关性(P<0.05)。结论mdm2基因高表达是肾母细胞瘤转移中的重要的分子生物学事件,检测肾母细胞瘤mdm2的表达情况对评估患儿的预后可能具有重要意义。Objective To study the expression of mdm2 genes in nephroblastoma in children and relationship between mdm2 gene and clinical pathological parameters, Methods The protein expressions of mdm2 in 24 case of nephroblastoma were detected with SP immunohistochemical method. The relationships between mdm2 expression and clinieopathological parameters were analyzed. Results The positive rates of mdm2 in 24 cases of nephroblastoma were correlated with lymph node metastasis, clinical stage and tumor differentiation. There was a positive relationship between mdm2 protein expression and clnicopathological parameters such as lymph node metastasis, clinical stage and degree of differentiation（P〈0.05）, Conclusions The high expression of mdm2 is an important molecular biological event during metastasis of nephroblastoma, Detecting the expressive level of mdm2 proteins in nephroblastoma may have certain reference value for evaluating the prognosis of children with nephroblostoma.

关 键 词：MDM2 肾母细胞瘤 儿童 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]