p16和PTEN抑癌基因蛋白在结直肠腺癌组织中的表达及临床意义  

Expression and significance of tumor supressor gene p16 and PTEN protein in colorectal cancer

作　　者：吴晓华[1] 张莘[1] 周文阔[1] 易喜贤[1] 吴涛[2] 徐惠绵[2] 

机构地区：[1]秦皇岛市第一医院普外科,066000 [2]中国医科大学第一附属医院肿瘤科,沈阳110001

出　　处：《中国肿瘤临床与康复》2006年第1期11-13,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨抑癌基因p16、PTEN蛋白的表达与结直肠腺癌的关系,为结直肠腺癌预后判断提供依据。方法采用免疫组织化学法检测55例结直肠腺癌标本中p16、PTEN蛋白的表达。结果p16蛋白阳性表达率70.9%,PTEN蛋白阳性表达率69.0%。p16、PTEN蛋白表达与肿瘤TNM分期、分化程度、淋巴结转移显著相关。结论p16、PTEN蛋白两者联合检测可做为结直肠腺癌预后的预测指标。Objective To investigate the relationship between the expression of tumor suppressor gene p16 and PTEN protein and the biologcal behaviors of colorectal cancer. Methods The expression of PTEN and p16 proteins in 55 colorectal cancer specimens was investigated with immunohistochemical technique using PTEN and p16 antibodies. The relationship between the expression of p16 and PTEN proteins and the clinicopathological parameters of colorectal cancer was analyzed. Results The frequency of expression of p16 and PTEN proteins was 70.9% and 69.0% in colorectal cancer, respectively. The expression of p16 and PTEN proteins was positively correlated with the TNM stage, differentiation degree and metastasis of colorectal cancer （P 〈0.05 respectively）. Moreover, there was a positive correlation between the p16 and PTEN protein expression in colorectal cancer （ r = 0. 49, P 〈 0. 005 ）. Conclusions Expression of tumor suppressor gene p16 and PTEN might be helpful in predicting the biological behavior and prognosis of colorectal cancer.

关 键 词：结直肠肿瘤 P16 PTEN 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤] R730.43[医药卫生—临床医学]