吉西他滨联合顺铂方案结合适形放疗治疗胰腺癌临床观察  

Clinical observation of gemcitabine and cisplatin chemotherapy combined with 3-D comformal radiotherapy in treating pancreatic carcinoma

作　　者：赵海燕[1] 张中民[1] 陈强华[1] 

机构地区：[1]山东省临沂市人民医院放疗中心,276003

出　　处：《中国肿瘤临床与康复》2006年第1期32-34,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察化疗联合三维适形放疗对不能手术胰腺癌的疗效。方法自2000年10月至2004年6月收治胰腺癌患者35例,三维适形放疗同步化疗(吉西他滨加顺铂)1周期,放疗结束后化疗3周期。结果客观有效率(CR+PR)为51.3%;止痛有效率93.3%;黄疸消退率75.0%;Karnofsky评分提高77.1%;中位生存期13.5个月。主要毒副反应为骨髓抑制及胃肠道反应。结论化疗与三维适形放疗结合可明显提高局控率,延长生存期。Objective To observe the efficacy of chemotherapy combined with 3-D conformal radio- therapy in treatment of patients with advanced pancreatic carcinoma. Methods A total of 35 patients with advanced pancreatic carcinoma from October 2000 through June 2004 were treated with gemcitabine and cisplatin chemotherapy combined with 3-D conformal radiotherapy. Results Effective rate confirmed by CT and MRI was 51.3% ,effective rate of analgesia was 93.3% ,jaundice disappearance rate was 75.0%. Karnofsky score was raised by 77.1% and median survival time was 13.5 months. The major toxicity was myelosuppression and gastrointestinal reaction. Conclusions Gemcitabine and cisplatin chemotherapy combined with 3-D comformal radiotherapy is an effective and valuable approach in treatment of the patients with advanced pancreatic carcinoma.

关 键 词：胰腺肿瘤/药物疗法 胰腺肿瘤/放射疗法 吉西他滨 

分 类 号：R735.9[医药卫生—肿瘤] R730.58[医药卫生—临床医学]