国产紫杉醇治疗上皮性卵巢癌周疗方案与月疗方案的比较  

Comparison of weekly dose and monthly dose of China-made paclitaxel for the treatment of epithelial ovarian carcinoma

作　　者：段微[1] 路虹[1] 范逢晓[1] 

机构地区：[1]北京妇产医院肿瘤科,100006

出　　处：《中国肿瘤临床与康复》2006年第1期73-74,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的比较紫杉醇每周一次给药和每月一次给药两种方法治疗上皮性卵巢癌的疗效和副反应，探讨不同给药方式的优缺点，力图寻找卵巢癌治疗的最佳方案。方法将57例上皮性卵巢癌患者分为2组，周疗组（WG）：紫杉醇60～80mg／m^2，iv（2h），d1，8，15；月疗组（MG）：紫杉醇135mg／m^2，iv（3h），d1；两组均与卡铂联用，3～4周为一疗程，所有病例至少使用3疗程。结果周疗组中位生存期为64个月，月疗组为67个月。周疗组晚期患者3，4年生存率分别为80．0％和58．3％；月疗组3，4，5年生存率分别为68．7％、39．3％和26．1％。周疗组胃肠道反应、白细胞减少、面色潮红等毒副反应发生率较月疗组少。结论使用每疗程分次给紫杉醇治疗上皮性卵巢癌的周疗法较传统月疗法在提高疗效和减少毒副反直方面有一定优势。Objective To compare the efficacy and toxicity between weekly dose and monthly dose of China-made paclitaxel in the treatment of epithelial ovarian carcinoma. Methods Fifty-seven patients were divided into two groups. Weekly dose therapy group（WG） ： paclitaxel was administered by iv infusion at a dose of 60-80 mg/m^2 in 2 hours （days 1,8,15 ） ; monthly dose therapy group（MG） ： paclitaxel was administered by iv infusion at a dose of 135 mg/m^2 in 3 hours（ day 1 ）. Carboplatin was administered by iv infusion on day 1. Four weeks were defined as one course in both groups. All patients were given at least 3 courses. Results The median survival time in WG was 64 months, and in MG was 67 months. In advanced ovarian cancer patients,the median survival rate in WG was 80.0% in 3rd year, 58.3% in 4th year;the median survival rate in MG was 68.7% in 3rd year, 39.3% in 4th year, 26.1% in 5th year（P 〈0.05）. Less side effect was seen in WG than in MG（ including hypersensitivity, gastrointestinal effect, and leucopenia）. Conclusion The weekly dose of paclitaxel for treatment of ovarian cancer patients is more effective and has less toxicity than monthly dose therapy.

关 键 词：卵巢肿瘤 周疗 月疗 紫杉醇 

分 类 号：R737.31[医药卫生—肿瘤] R730.53[医药卫生—临床医学]