中国辽宁汉族群体DNA修复基因:ERCC2/XPDA35 931C遗传多态性  

Polymorphism of DNA Repair Genes: ERCC2/XPD A35 931C in Han Chinese from Liaoning Province

作　　者：祁荣[1] 马业罡[2] 刘大为[3] 孙中芙[1] 郭丽[1] 尹娇杨[1] 

机构地区：[1]沈阳医学院生物学教研室,110043 [2]辽宁省肿瘤医院胸外科,沈阳110042 [3]中国人民解放军沈阳军区总医院,沈阳110016

出　　处：《国际遗传学杂志》2006年第1期8-10,25,共4页International Journal of Genetics

基　　金：国家自然科学基金项目(No.30571016);辽宁省教育厅高等学校科学研究项目(No.05L438)

摘　　要：目的研究DNA修复基因ERCC2/XPDA35 931C及其遗传多态性在保护维持基因组整体性及抗癌发生过程中的重要作用。方法应用PCR-RFLP方法调查了中国辽宁汉族群体DNA修复基因:ERCC2/XPDA35 931C遗传多态性。结果ERCC2/XPDA35 931C基因型频率:AA=0.98;AC=0.05;CC=0.00,基因型分布符合Hardy-Weinberg遗传平衡定律(P=0.77);ERCC2/XPDA35 931C等位基因频率:A=0.98;C=0.02。结论研究结果与前期所报道的其他群体的该等位基因频率分布进行比较,辽宁汉族群体该SNP频率分布与亚洲大多数群体的频率分布特点相似。Objective To study the important mle of DNA repair gene ERCC2/XPD A35 931C and its genetic polymorphism in maintaining the integrity of the genome and protecting against mutations that can lead to cancer. Methods We studied the genetic polymorphism of ERCC2/XPD A35 931C in Han Chinese from Liaoning Province by PCR - RFLP method. Results The genotype frequencies were 0.98（AA）, 0.05（AC）, and 0.00（CC） ; and the allele frequencies were 0.98（A）and 0.02（C）, respectively. Conclusion The present study results were compared with ones of the previously reported control populations. Frequency distribution of ERCC2/XPD A35 931C among Han Chinese in Liaoning is similar to that of most population in Asia.

关 键 词：DNA修复基因 ERCC2/XPD A35 931C 遗传多态性 中国汉族 

分 类 号：R394[医药卫生—医学遗传学]