低剂量X射线照射诱导小鼠生殖细胞适应性反应的研究  

CYTOGENETIC ADAPTIVE RESPONSE INDUCED BY LOW DOSE RADIATION IN MOUSE GERM CELLS

作　　者：王彬[1] 姜杰[1] 蔡露[1] 王献理[1] 

机构地区：[1]白求恩医科大学放射医学研究所

出　　处：《辐射防护》1996年第1期67-71,共5页Radiation Protection

基　　金：国家自然科学基金

摘　　要：本实验以０．０５—０．３０Ｇｙ的Ｘ射线预先对雄性昆明种小白鼠照射，４ｈ后再以１．５ＧｙＸ射线照射，观察其精原细胞、初级精母细胞染色体畸变和精原干细胞染色体易位的适应性反应。结果表明，预先照射剂量在０．０５—０．３０Ｇｙ之间都能诱导出适应性反应；剂量越小，诱导出的适应性反应越明显，最佳剂量为０．０５Ｇｙ。说明生殖细胞同体细胞一样，预先给予小剂量照射可以降低随后较大剂量照射所造成的损伤，存在着适应性反应现象。he adaptive response for chromosome aberrations in sperm cells and for translocation in spermatogonia was observed in male mice which previously received an exposure to X rays at doses of 0. 05-0. 3 Gy and after 4 h, another exposure at a dose of 1. 5 Gy.The results indicate that the adaplive response can be induced with adaptive doses from 0. 05Gy to 0. 30 Gy and that the lower the adaptive dose, the more obvious the magnitude of adaptive response induced, suggesting that in germ cells, as in somatic cells, there also is the adaptive response, i. e. the phenomenon that previous exposure to a lower dose of radiation can reduce the damage caused by subsequent exposure to a higher one.

关 键 词：低剂量照射 生殖细胞 染色体畸变 适应性反应 

分 类 号：R818.807[医药卫生—放射医学] R818.02[医药卫生—临床医学]