ROC曲线评价AFU及AFP对原发性肝癌的诊断价值  

Application of ROC curve in the analysis and evaluation of the diagnostic value of AFU and AFP in PHC

作　　者：何惠[1] 刘基铎[1] 周迎春[1] 余崇镐[1] 李红[1] 陈海鸣 

机构地区：[1]广州中医药大学第一附属医院检验科,510405

出　　处：《国际检验医学杂志》2006年第2期118-120,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨甲胎蛋白(AFP)、αL岩藻糖苷酶(AFU)二者联合检测对原发性肝癌(PHC)患者的诊断价值。方法应用受试者工作特性曲线(ROC)对80例PHC患者及40例健康体检者的AFP、AFU、AFP与AFU联合检测结果进行分析评价。结果AFP与AFU检测指标在两组资料间比较均有统计学意义(P<0.005)。PHC患者的AFP、AFU、AFP与AFU联合检测在ROC曲线下面积分别为0.78、0.81、0.91。AFP、AFU对PHC的临床诊断临界点分别为400μg/L、80U/L。结论通过ROC曲线评价,AFP与AFU联合检测优于AFP、AFU的单项检测。Objective To study the diagnostic value of AFP,AFU and the combined detection of AFU and AFP in PHC. Methods To analyse the detection results of AFP,AFU and AFP and AFU from 80 PHC patients and 40 healthy controls by ROC curve. Results AFP and AFU were significantly different between them （P〈0.05）. The area under ROC curve of AFP, AFU and AFP combined with AFU from PHC patients were 0.78,0.81 and 0.91 respeetively. The clinical diagnostic critieal point of AFP and AFU in PHC were 400μg/L and 80U/L. Conclusion The combined detection of AFU and AFP is better than AFP or AFU individual detection.

关 键 词：ROC曲线 癌 肝细胞 肝肿瘤 甲胎蛋白类 Α-L-岩藻糖苷酶 

分 类 号：R735.7[医药卫生—肿瘤]