急性胰腺炎患者白细胞介素18和白细胞介素15的变化意义  

Changes of serum level of IL-18 and IL-15 In patients with acute pancreatitis

作　　者：贺丽[1] 陈少夫[2] 傅力 潘丽丽[4] 

机构地区：[1]沈阳医学院沈洲医院消化科,辽宁省沈阳110002 [2]中国医科大学盛京医院消化科 [3]民航沈阳医院 [4]中国医科大学盛京医院中心实验室

出　　处：《中国基层医药》2006年第1期56-57,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨白细胞介素18(IL-18)和白细胞介素15(IL-15)在急性胰腺炎(AP)发病机制中的作用。方法采用酶联免疫吸附法(ELISA)检测19例轻型急性胰腺炎(MAP)患者和7例重症急性胰腺炎(SAP)患者血清IL-18和IL-15的浓度,分析它们之间的相关性。结果血清IL-18和IL-15的表达在SAP组明显高于MAP组,两组中存在显著差异[IL-18(78.32±15.45)ng/L vs(28.21±13.18)ng/L,P<0.01;IL-15(42.17±19.15)ng/L vs(5.88±2.01)ng/L,P<0.01]。血清IL-15和IL-18在MAP组及SAP组均呈显著正相关(P<0.01)。结论血清IL-18和IL-15参与了急性胰腺炎的炎症反应过程,可能是预测急性胰腺炎严重程度的指标。Objective To investigate the role of interleukin-18 （IL-18） and int.erleukin-15 （IL-15） in the mechanism of acute panereatitis. Methods The serum levels of IL-18 and IL-15 were detected by enzyme-linked immunosorbent assay（ELISA） in SAP group（ n = 7） and MAP group（ n = 19）. The relationship between IL-18 and IL-15 were analyzed. Results SAP group was compared with the MAP group： IL-18 （78.32 ± 15.45）ng/L vs （28.21 ± 13.18）ng/L,P〈0.01 and IL-15 （42.17 ± 19. 15）ng/L vs （5.88 ±2.01）ng/L,P〈0.01,in SAP group was higher than that in MAP group obviously;There was significant positive correlation between IL-15 and IL-18 in both MAP group（r=0.95,P〈0.01） and in SAPgroup（r=0.91,P〈0.01）.Conclusion IL-18 and IL-15 play important roles in the development of acute pancrcaritis, they may be valuable indexes to predict the severity of AP.

关 键 词：胰腺炎 白细胞介素18 白细胞介素15 急性胰腺炎 酶联免疫吸附法 发病机制 

分 类 号：R576[医药卫生—消化系统] R392.12[医药卫生—内科学]