甲状腺功能亢进症患者^(131)Ⅰ治疗后染色体畸变率及血清过氧化脂质、超氧化物歧化酶的检测  

Detection of chromosome aberration rate and serum LPO and SOD after ^(131)I therapy for hyperthyroidism

作　　者：罗贵有[1] 李启运[2] 王长花[2] 

机构地区：[1]暨南大学医学院第二附属医院放射免疫室 [2]暨南大学医学院第二附属医院遗传室

出　　处：《华中医学杂志》2006年第1期15-16,共2页Central China Medical Journal

摘　　要：目的探讨甲状腺功能亢进症(甲亢)患者^(131)I治疗后染色体畸变率与血清过氧化脂质(LPO)和超氧化物歧化酶(SOD)的关系。方法74例甲亢患者在^(131)I治疗前后和30例健康对照者分别检测染色体畸变率和血清LPO、SOD。结果甲亢患者^(131)I治疗后染色体畸变率和LPO显著增高,SOD明显降低。染色体畸变与LPO呈显著正相关,与SOD呈显著负相关。结论甲亢患者^(131)I治疗后可引起染色体畸变率增高和自由基含量增加。Objective To investigate the relationship between chromosome aberration rate and serum lipoperoxide （LFO）, superoxide dismutase （SOD） after 131^Ⅰ therapy for Graves＇ hyperthyroidism. Methods Chromosome aberration rate and levels of serum LPO and SOD were determined in 74 patients with hyperthyroidism before and after 131^Ⅰ therapy. Thirty healthy people served as controls Results In the patients with hyperthyroidism, chromosome aberration rate and LPO levels were significantly increased, whereas SOD was significantly decreased alter therapy. Chromosome aberration rate was positively correlated with LFO and negatively with SOD. Conclusion 131^Ⅰ therapy signifieantly increased the chromosome aberration and free radicae level in the patients with hyperthyroid.

关 键 词：甲状腺功能亢进症 放射性碘 染色体畸变 过氧化脂质 超氧化物歧化酶 

分 类 号：R581.1[医药卫生—内分泌]