原发性高血压并发心脑血管疾病患者的临床表现分析  

The Clinical Characteristic of Patients with Essential Hypertension Complicating Cardiovascular and or Cercbrovascular Diseases.

作　　者：张明华[1] 刘国树[1] 覃秀川[1] 刘蓉[2] 

机构地区：[1]解放军总医院南楼二科,北京100853 [2]解放军总医院门诊内科

出　　处：《中华临床医学杂志》2006年第1期15-17,共3页Chinese Journal of Clinical Practical Medicine

摘　　要：目的 研究高血压伴冠心病和／或脑血管病患者的临床特征，并探讨其临床意义。方法 对55例高血压伴冠心病和／或脑血管病患者，进行动脉硬化指数（AST）测定，并检测患者的血尿酸、血糖．血脂、肌酐、尿素氖等血液生化指标及一般情况。另选不伴有冠心病．脑血管病的高血压患者63例作为对照。结果 与高血压对照组比较，高血压件冠心病和／或脑血管病患者的年龄大、病史时间长，ASI、脉压、血尿素氮明显增高（均P〈0．01）；收缩压、血尿酸、总胆固醇、肌酐也增高（均P〈0．05）；而舒张压（P〈0.01），心率却较低（P〈0．05）。多因素logistic回归分析显示：高血压患者并发心脑血管疾病的独立相关因素有脉压、血肌酐、年龄（0R=1．204，1.120，1．099；P=0028，0．045，0．039）。结论 年龄大、病史时间长、高尿酸、高血脂、高脉压、动脉硬化、肾功能下降与高血压患者并发心脑血管疾病相关联。脉压、血肌酐水平和年龄是高血压患者并发心脑血管疾病的独立相关因素。Objective To investigate the clinical characteristic of patients with essential hypertension complicating coronary heart diseases and or cerebral vascular diseases. Methods 118 patients with essential hypertension were recruited and divided into two groups according to their clinical diagnosis. They were simple hypertensive patients （n=63） and hypertensive patients complicating coronary heart diseases and or cerebral vascular diseases（n=55）. The demographic characteristics, arterial stiffness index and blood biochemical parameters were measured and compared between the two groups.Results Comparing with simple hypertensive patients, there were older age, longer hypertensive history, higher values of arterial stiffness index, pulse pressure, serum creatinine（all P〈0.01 ）, higher values of systolic blood pressure, blood uric acid, total cholesterol, blood urea nitrogen（all P〈0.05）, but lower values of diastolic blood pressure（P〈0.01）, heart ratc（P〈0.05）in the hypertensive patients complicating coronary heart diseases andor cerebral vascular diseases.Logistic Regression analysis showed that pulse pressure, serum creatinine and age（OR= 1.204, 1.120, 1.099; P=0.028, 0.045, 0.039, respectively） were independent risk factors for the hypertensive patients complicating coronary heart diseases and or cerebral vascular diseases. Conclusion Old age, long hypertensive history, high values of blood uric acid, total cholesterol, arterial stiffness and the cutting down of kidney function may be associated with essential hypertension complicating coronary heart diseases and or cerebral vascular diseases.Its potential independent risk factors are pulse pressure, serum ereatinine and age.

关 键 词：原发性高血压 心脑血管疾病 尿酸 动脉硬化指数 

分 类 号：R734[医药卫生—肿瘤]