胸腔内联合灌注博莱霉素和恩格菲治疗恶性胸腔积液的疗效评价  

Treatment of Malignant Pleural Effusion Using Dleomysin and En-Ge-Fei Intrapleurally Infusion

作　　者：沈四新[1] 江晓肖[1] 方鹏[1] 陈达伟[1] 陈少明[1] 

机构地区：[1]解放军第117医院呼吸科,浙江杭州310013

出　　处：《临床军医杂志》2006年第1期20-22,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨胸腔内联合灌注博莱霉素和恩格菲治疗恶性胸腔积液的临床疗效及毒副反应。方法经病理确诊的恶性胸腔积液49例,胸腔置管引流术排尽胸液后,随机分为两组,治疗组(A组25例),在胸腔内灌注博莱霉素45 mg+恩格菲3 000 U,对照组(B组24例)在胸腔内灌注博莱霉素45 mg,1周后重复1次,观察疗效、生活质量及毒副反应。结果A组完全缓解(CR)12例,部分缓解(PR)9例,总有效率84%;B组完全缓解(CR)6例,部分缓解(PR)7例,总有效率54%,两者比较差异有显著性(P<0.05)。Karnokky评分>70分治疗组较对照组有显著提高(P<0.05)。毒副反应:A组有发热6例(24%),胸痛4例(16%),恶心2例(8.0%),B组有发热5例(21%),胸痛3例(13%),恶心2例(8.3%),两组比较差异无显著性(P>0.05)。结论胸腔内联合灌注博莱霉素和恩格菲是一种有效、副反应小、可耐受的方法。Objective To evaLuate the efficacy and toxicityof b1 eomysin and En-Ge-Fei in the treatment of malignant pleura1 effusion. Methods 49 patients with malignant pleural effuslon were randomized into groups, bleomysin 45 mg＋ En-Ge-Fei 3000 U were infusioned into pleural cavity in therapy group （groupA） , and bleomysin 45mg in group （groupB）. the treatm-ent was repeated after a week and observed the efficacy, t-oxicl ties and quality of llfe for four weeks. Results The overall response rate was 84% in group A and 54% in group B. There was statistical difference in two group （/0. 05 ）. TheKarnofsky score is higer in group A than In group B. The sys-temic toxicity was mild, including fever （24%） , pleuritic pai-n （ 16% ）, nansea （8. 0% ） in group A and fever （21%）, pleuritic pl-ain （ 13% ）, nansea （8. 3% ） in group B. There was not statistical dlffercncein two group （P 〉 0. 05 ）. Conclusion The treatment to use bleomysin and En-Ge-Fei through thoracic tube is re-garded as effective, slight side. effect and well toleratedfnethod for malignant pleural effusion.

关 键 词：恶性胸腔积液 博莱霉素 恩格菲 灌注 

分 类 号：R734.2[医药卫生—肿瘤]