急性白血病患者输注血小板制剂的指征探讨  

Analysis of Platelet Transfusion in Acute Leukemia Patients

作　　者：张新华[1] 王军[1] 谢红[1] 熊金元[1] 刘玉英[1] 李沙[1] 

机构地区：[1]广州军区武汉总医院,武汉430070

出　　处：《内科急危重症杂志》2006年第1期23-25,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨急性白血病患者输注血小板制剂的指征。方法:总结92例急性白血病患者在接受诱导缓解化疗、巩固化疗及强化治疗期间的出血表现、血小板计数变化及输注血小板情况。结果:接受诱导缓解化疗的急性白血病患者,出血倾向轻重不一,输注血小板的比例为31.5%;接受巩固化疗患者出血倾向较轻,输注血小板者比例为10.9%;接受中大剂量强化治疗的患者,出血倾向重,输注血小板比例为52.9%。结论:完全缓解后接受巩固及强化治疗的患者,如不伴发严重感染等加重出血的危险因素,可将血小板输注指征定为5×109/L;接受诱导缓解化疗,或接受巩固、强化治疗伴发严重感染的急性白血病患者,输注血小板指征可定为10×109/L或更高。Objective： To explore the indication of platelet transfusion in the-acute leukemia patients. Methods： Hemorrhagic tendencies , peripheral blood platelet counts and volumes of platelet infusion during different phase of chemotherapy in 92 patients were summarized. Results ： The patients subjected to remission-induction chemotherapy had mild to severe bleeding trends , the platelet transfusion rate was 31.5%; the patients subjected to ordinary dose consolidation chemotherapy showed mild bleeding tendency, the platelet transfusion rate was 10. 9% and those received postremission intensive chemotherapy had severe bleeding trend , 52. 9% of patients necessitated platelet support. Conclusion ： For the indications of platelet infusion, the thresholds of platelet count may be recommend as 5×10^9/L, 5×10^9/L and 10×10^9/L according to the different phase of chemotherapy and ordinary dose consolidation chemotherapy, remission-induction chemotherapy and postremission intensive chemotherapy respectively. The thresholds should be higher if the patients suffer from serious infections or bleeding at any time.

关 键 词：急性白血病 化疗 方式 血小板输注 

分 类 号：R733.71[医药卫生—肿瘤]