MMP_2、MMP_9、TIMP_1、TIMP_2在非小细胞肺癌中的表达及临床病理学意义  

Clinicopathological Significance of MMP_2,MMP_9,TIMP_1 and TIMP_2 Expressions in Human Non-small Cell Lung Cancer

作　　者：周建华[1] 王文祥[2] 文继舫[1] 曹慧秋[1] 沈明[1] 

机构地区：[1]中南大学湘雅医学院病理学系,湖南长沙410078 [2]湖南省肿瘤医院

出　　处：《实用预防医学》2006年第1期23-26,共4页Practical Preventive Medicine

摘　　要：目的探讨基质金属蛋白酶MMP2、MMP9及其抑制剂TIMP1、TIMP2在非小细胞肺癌(NSCLC)中的表达及临床病理学意义。方法采用免疫组织化学S-P法,分别检测43例NSCLC组织、15例正常支气管粘膜上皮组织中MMP2、MMP9、TIMP1及TIMP2的蛋白表达。结果MMP2、MMP9、TIMP1及TIMP2在43例NSCLC中的阳性表达率(分别为79.1%、74.4%、55.8%及60.5%)明显高于正常支气管粘膜上皮组织(分别为26.7%、26.7%、20.0%及26.7%)(P<0.01或P<0.05);MMP2、MMP9的表达随着病理分级和临床分期增加而有增高趋势;而TIMP1、TIMP2的阳性表达则呈下降趋势。MMP2、MMP9、TIMP1及TIMP2的阳性表达率与患者淋巴结转移和3年生存期密切相关(P<0.05),但与患者的临床参数均无明显关系(P>0.05)。结论MMP2、MMP9、TIMP1及TIMP2的过度表达与NSCLC的发展、淋巴结转移及预后有密切关系,可作为临床评估NSCLC的进展及预测其转移潜能和预后的重要指标之一。Objective To study the clinicopathological significance of MMP2, MMP9, TIMP1 and TIMP2 expressions in non- small cell lung cancer（NSCLC）. Methods The expressions of MMP2, MMP9, TIMP1 and TIMP2 in 43 patients with NSCLC and 15 normal epithelial tissues of the lung were detected by immunohistochemical S - P method. Results The positive rates of MMP2, MMP9, TIMP1 and TIMP2 in NSCLC were 79.1%, 74.4%, 55.8% and 60.5% respectively, which were significantly higher than those in normal epithelial tissues of the lung （P〈 0.05 or P〈 0.01 ）. The positive rates of MMP2 and MMP9 were significantly higher in stage Ⅲ than those in stage Ⅰ＋ Ⅱstage NSCLCs（P〈 0.0.5）. The positive rates of TIMP1 and TIMP2 were much lower in grade 3 and stage Ⅲ than those in grade Ⅰ and stage Ⅰ NSCLC（P〈0.05）. The expressions of MMP2, MMP9, TIMP1 and TIMP2 were closely associated with lymph node metastasis and 3 - year survival rate of NscLc（P〈 0.05）, but not to other clinical parameters（ P 〉 0.05）. Conclusions over expressions of MMP2, MMP9, TIMP1 and TIMP2 are closely correlated to the progression, metastasis and poor prognosis of NSCLC. It might be useful in evaluation of the NSCLC progression, and to predict the metastasis and prognosis.

关 键 词：非小细胞肺癌 免疫组织化学 基质金属蛋白酶 组织金属蛋白酶抑制剂 

分 类 号：R36[医药卫生—病理学]