放射治疗联合顺铂加替加氟治疗中晚期食管癌临床观察  

Radiation combination with DDP plus tegafur treated for advanced esophageal cancer

作　　者：李建哲[1] 张新丽[1] 田瑞华[1] 程圆圆[1] 

机构地区：[1]山东省泰安市中心医院肿瘤内科,271000

出　　处：《肿瘤研究与临床》2006年第2期115-117,共3页Cancer Research and Clinic

摘　　要：目的探讨中晚期食管癌单纯放疗与放疗+化疗的治疗效果。方法对148例中晚期食管癌患者随机分为两个组(各74例),两组均给以60～65Gy/6～6.5周的常规放疗,化放组在放疗前1周、放疗第3周及放疗结束后加顺铂(DDP)、替加氟(Tegafur)化疗,于放疗全程加用替加氟口服,共4个周期。结果近期疗效单放组总有效率为81.1%,化放组为90.5%,两组比较差异无统计学意义(χ2=2.719,P=0.09);1,3,5年生存率分别为单放组43.2%,16.2%,9.5%,化放组71.6%,33.8%,21.6%,化放组生存率高于单放组,两组比较差异有统计学意义(χ2=8.684,P<0.01),化放组的毒副反应主要为食管黏膜反应和白细胞下降,均能耐受。结论应用DDP+替加氟方案化疗可提高中晚期食管癌放射治疗的疗效。Objective To study on the curative effect of DDP and Tegafur plus radiation for advanced cancer of esophagus. Methods 148 Patients with advanced cancer of esophagus were randomized into two groups （each 74）, one group were accepted radical radiotherapy followed by DDP and Tegafur （chemoradiotherapy group）,the other group were accepted radical radiotherapy only （radiotherapy group）, radiotherapy in both groups was similar （60 - 65 Gy/6-6.5 W with routine fractionation）. Results The effect was 81.1% in radiotherapy group and 90.5 % in chemoradiotherapy group, the difference in effect was no statistically significant （x^2=2.719, P =0.09）, The 1, 3 and 5-year survived rates were 43.2 %, 16.2 %, 9.5 % respectively in radiotherapy group and 71.6 %, 33.8 %, 21.6 % respectively in chemoradiotherapy group. The survival rates in chemoradiotherapy group were all higher than that in radiotherapy group, the difference in effect was statistically significant （x^2=8.684, P 〈0.01）, The main side effect of chemoradiotherapy were the esophagus mucous membrane reaction and the leukopenia, but can be endured. Conclusions The result shows that chemoradiotherapy for advanced cancer of esophagus may improve the effect than radiotherapy alone.

关 键 词：放射治疗 顺铂 替加氟 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]