细胞形态测量和DNA含量与AgNOR计数在鼻咽良恶性病变诊断中的应用  

Nuclear Morphometry DNA Cytometry and AgNOR Count in the Benign Pathological Change and Nasopharyngeal Carcinoma

作　　者：李琳[1] 杨正中[1] 张会华[1] 李咸龙[1] 欧阳明[1] 崔英[1] 李丽波[1] 

机构地区：[1]云南省第一人民医院,云南大学图像分析室,昆明医学院病理解剖教研室

出　　处：《肿瘤防治研究》1996年第1期18-20,共3页Cancer Research on Prevention and Treatment

摘　　要：用图像分析仪对正常鼻咽粘膜上皮１０例，单纯增生或化生１８例，异型增生或化生２０例，鼻咽癌２４例进行核形态和ＤＮＡ含量与核仁组成区嗜银蛋白（ＡｇＮＯＲ简称）计数检测，综合各项测量指标进行多元判别分析，结果发现：正常粘膜上皮，单纯增生和鼻咽癌诊断准确率均为１００％，异型增生为８５％，提示细胞学定量分析是诊断鼻咽良恶性病变的一种比较可靠的方法。异型增生的细胞核形态、ＤＮＡ含量和ＡｇＮＯＲ计数测量值的个体差异较大，显示异型增生上皮生物学性质的个体差异。Abstract Nuclear morphometry DNA cytometry and AgNorg count were measured in 10 normal nasopharynx epithelium, 18 simple proliferation, 20 heterotypic proliferation and 24 nasopharyngeal carcinoma. Multivariate discrimination analysis was used to the herign pathological change malignant tumors of nasopharynx. The discrimination rate was 100% for normal nasopharynx epithelium, simple proliferation and nasopharyngeal carcinoma. It was 85% for heterotypic proliferation. These results showed that quantitive cytological analysis is effective and reproducible in the tumors of nasopharynx.

关 键 词：鼻咽肿瘤 诊断 细胞形态学 DNA AGNOR 

分 类 号：R739.63[医药卫生—肿瘤] R730.43[医药卫生—临床医学]