AgNOR检测对宫颈癌预后的意义  

Significance of AgNORs in the Progosis of Cervical Squamous Carcinoma

作　　者：李庆菊[1] 刘秀云[1] 陈正勤[1] 宋现让[1] 王联华[1] 张素兰[1] 梁焕玲[1] 张华[1] 

机构地区：[1]山东省肿瘤防治研究院,山东省中医院

出　　处：《肿瘤防治研究》1996年第1期21-22,共2页Cancer Research on Prevention and Treatment

摘　　要：对７３例随访１０年以上的宫颈鳞癌进行ＡｇＮＯＲ计数分析，发现组织学Ｄ级的肿瘤细胞核内ＡｇＮＯＲ均值高于组织学Ⅰ级者为５．５３±１．４７及４．４０±１．３４）。１０年生存率亦有差异性，ＡｇＮＯＲ均值≥５者１０年生存率为１８％，而＜５的１０年生存率为４６％（Ｐ＜０．０２）。结果表明，ＡｇＮＯＲ计数与宫颈鳞癌的组织学分级及临床预后有关。本文认为ＡｇＮＯＲ计数可作为一种肿瘤定量指标，对判定肿瘤恶性程度，预测宫颈癌预后具有一定参考价值。AgNORs were analyzed with AgNOR staining in 73 specimens of cervical squamous carcinoma. The results showed that AgNORs of the specimens with Ⅱ histological grade were higher than that of grade Ⅰ, (5. 53±1. 47and, 4. 40±1. 34, respectively), and the patients whose AgNORs were≥5. 0, have a lower 10-year survival rate than the patients whose AgNORs were< 5. 0, P<0. 02. This indicated that there was a good correlation between AgNORs and histolgical grade or prognosis of the cervical squamous carcinoma,AgNORs could be regarded as a valuable index to judge the malignant grade and the prognosis of cervical squamous carcinoma.

关 键 词：宫颈癌 AGNOR 细胞诊断 预后 

分 类 号：R737.330.4[医药卫生—肿瘤]