学习训练对谷氨酸单钠所致大鼠海马损伤的神经保护作用  

NEUROPROTECTIVE EFFECTS OF LEARNING ON GLUTAMATE-INDUCED NEURONAL DAMAGE IN RAT HIPPOCAMPUS

作　　者：张金平[1] 白文忠[1] 史玉兰[1] 金凤霞[1] 

机构地区：[1]河北师范大学生命科学院,河北石家庄050016

出　　处：《中国应用生理学杂志》2006年第1期36-39,共4页Chinese Journal of Applied Physiology

基　　金：河北省自然科学基金(399203)

摘　　要：目的：探讨学习训练对谷氨酸神经毒性的保护作用。方法：在SD大鼠生后第3～9d腹腔注射谷氨酸单钠复制谷氨酸毒性模型，在1月龄和2月龄时训练大鼠学会以明暗辨别来获得食物，3月龄时取脑，在光镜下计数海马内存活神经元数，电镜下观察海马CA1区的超微结构，并计数突触数，测量突触活性带长度。结果：学习训练组海马CA3区和CA4区内的存活神经元数、海马CA1区内的突触数和突触活性带长度均大于非学习组，结论：结果提示学习训练可在一定程度上减轻MSG对海马的损伤。Aim： To investigate the neuroprotective effect of learning on glutamate-induced neuronal damage. Methods： SD rats were intraperitoneally injected with monosodium glutamate（MSG） during the period of 3- 9 days after born, and were trained to find their food by light-dark discrimination at 1 month old or 2 months old. At 3 months old, all rats were killed and their brains were taken out and cut into sections and ultrathin sections. The survival neurons in hippocampus were counted under light microscope, and under electric microscope, the ultrastructure, the numbers of synapses and the length of synaptic active zone in fields CA1 of hippocampus were observed. Results： The survival neurons in field CA3 and CA4, the number of synapses and the length of synaptic active zone in field CA1 of hippocampus increased in learning group than non-learning group. Conclusion： These finding indicate that discriminative learning can alleviate neuronal injury of hippocampus induced by MSG.

关 键 词：学习 神经保护 谷氨酸单钠 海马 

分 类 号：R338.64[医药卫生—人体生理学]