硫酸锌对肠系膜上动脉闭塞性休克后肺损伤的治疗作用  

THERAPEUTIC EFFECT OF ZINC SULFATE ON LUNG INJURY DURING SUPERIOR MESENTERIC ARTERY OCCLUSION(SMAO) SHOCK

作　　者：景友玲[1] 赵春秀[1] 段国贤[1] 王艳蕾[1] 胡永奇[1] 张连元[1] 

机构地区：[1]华北煤炭医学院生理教研室,河北唐山063000

出　　处：《中国应用生理学杂志》2006年第1期90-93,共4页Chinese Journal of Applied Physiology

基　　金：河北省煤炭厅基金资助(96141600451)

摘　　要：目的:探讨硫酸锌对肠系膜上动脉闭塞性(SMAO)休克后肺损伤的治疗作用及其机制。方法:行腹部手术分离出肠系膜上动脉并夹闭,2h后松夹,复制家兔SMAO休克模型。检测给与硫酸锌后SMAO休克家兔血浆及红细胞膜丙二醛(MDA)、红细胞超氧化物歧化酶(SOD)、血浆黄嘌呤氧化酶(XOD)含量;同时检测肺组织MDA、SOD和肺表面活性物质(PS)的含量,并观察小肠和肺的病理改变。结果:硫酸锌可使MDA及XOD含量降低,且可防止SOD和PS减少,避免了SMAO休克后肺损伤的进行性加剧。结论:SMAO休克并发急性肺损伤与组织氧化过程代谢紊乱有关,硫酸锌通过其稳膜作用能减轻或在一定程度上防止休克后肺损伤的发生和发展。Aim： To study preventive and therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion （SMAO） shock and their mechanism of action. Methods： Model of rabbit SMAO shock was made. The effect of zinc sulfate on the malondialdehyde（MDA） in erythrocyte membrane and plasma, oxidase（XOD） in plasma, superoxide dismutase（SOD） in erythrocyte and MDA, SOD and pulmonary surfactant （PS） in lung tissues homogenate were observed. Results： The administration of zinc sulfate decreased MDA and XOD, prevented the reduction of SOD and PS, and alleviated lung injury. Conclusion： It is suggested that lung is injuryed during SMAO shock and zinc sulfate possesses preventive and therapeutic effect, through stabilized membrane.

关 键 词：硫酸锌 休克肺 脂质过氧化 肺表面活性物质 

分 类 号：R363.2[医药卫生—病理学]