Hollow fiber liquid-supported membrane technology for enantioseparation of racemic salbutamol by combinatorial chiral selectors  

作　　者：焦飞鹏 黄可龙 彭霞辉 赵学辉 于金刚 

机构地区：[1]School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China,School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China [2]School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

出　　处：《Journal of Central South University of Technology》2006年第1期39-43,共5页中南工业大学学报（英文版）

基　　金：Project(20376085)supportedbytheNationalNaturalScienceFoundationofChina;project(03JJY3020)supportedbytheProvinceNaturalScienceFoundationofHunan

摘　　要：Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chiral selectors, which were dissolved in toluene organic solvent. The effects of molar concentration ratios of salbutamol to combinatorial chiral selectors, and the pH value of buffer solution on enantioseparation were investigated. The results show that when the molar concentration ratio is 2∶1∶1, the maximum separation factor and enantiomer excess are 1.49 and 19.74%, respectively, and the R-enantiomer flux is more than S-enantiomer; the pH value of buffer solution influences the performances of enantioseparartion obviously, and the appropriate range of pH value is 7.07.2.Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chiral selectors, which were dissolved in toluene organic solvent. The effects of molar concentration ratios of salbutamol to combinatorial chiral selectors, and the pH value of buffer solution on enantioseparation were investigated. The results show that when the molar concentration ratio is 2 ： 1 ： 1, the maximum separation factor and enantiomer excess are 1.49 and 19.74%, respectively, and the R-enantiomer flux is more than S-enantiomer; the pH value of buffer solution influences the performances of enantioseparartion obviously, and the appropriate range of pH value is 7.0-7.2.

关 键 词：ENANTIOSEPARATION liquid-supported membrane hollow fiber combinatorial chiral selector racemic salbutamol 

分 类 号：O621.2[理学—有机化学]