整合蛋白α5、β1亚基在前列腺癌中的表达及其临床意义  

Correlation between Integrin Subunits α5 and β1 Expressions in Prostate Cancer and Its Clinical Implication

作　　者：陈海蛟[1] 王浩[2] 张立[1] 张永康[1] 王国民[1] 

机构地区：[1]复旦大学附属中山医院泌尿外科,上海200032 [2]复旦大学上海医学院糖复合物重点实验室,上海200032

出　　处：《中华男科学杂志》2006年第2期148-150,共3页National Journal of Andrology

摘　　要：目的:研究整合蛋白α5、β1亚基在前列腺癌(PCa)中的表达及与病理分级和临床分期的关系。方法:采用免疫组化ABC法检测30例正常前列腺组织和30例PCa石蜡标本中整合蛋白α5、β1亚基的表达水平。结果:与正常前列腺组织相比,PCa组织整合蛋白α5、β1亚基表达减弱或消失(P<0.05)。整合蛋白α5、β1亚基表达水平随PCa的病理分级(分化程度)升高而升高,随临床TNM分期的升高而降低。结论:在正常前列腺组织中整合蛋白α5、β1亚基的表达比PCa中高,其表达水平与PCa的病理分级呈正相关关系,和临床分期呈负相关关系,整合蛋白α5、β1亚基的研究为PCa的诊断及增殖提供了一个有价值的指标。Objective： To explore the correlation between the expression of integrin subunits α5 and β1 in prostate cancer （PCa） and its clinicopathological data including tumor grade and clinical stage. Methods ： Expressions of integrin subunits α5 and β1 were examined in 30 cases of PCa and 30 cases of normal prostatic tissues by immunohistochemical assay. Results： Expressions of integrin subunits α5 and β1 in PCa were lower than those in normal prostatic tissues（ P 〈 0.05 ） respectively. Conclusion： Compared with normal prostatic tissues, expressions of integrin subunits α5 and β1 in PCa were rather weaker or even faded. Expressions of integrin subunits α5 and β1 revealed an positive correlation with tumor＇s Gleason grade and negative with clinical TNM stage. The results indicate that integrin subunits α5 and β1 have potential values in the diagnosis and are predictable indices in the proliferation of PCa.

关 键 词：前列腺癌 整合蛋白 α5亚基 β1亚基 

分 类 号：R737.25[医药卫生—肿瘤]