放烧复合伤大鼠心肌细胞膜β－肾上腺素能受体密度变化的实验研究  

Changes ofβ-adrenoceptor concentration in myocardial membrane of rats subjected to combined radiation-burn injury

作　　者：徐辉[1] 陈宗荣[1] 

机构地区：[1]重庆第三军医大学预防医学系防原教研室

出　　处：《中华放射医学与防护杂志》1996年第2期81-87,共7页Chinese Journal of Radiological Medicine and Protection

基　　金：国家"八五"攻关课题

摘　　要：采用６０Ｃｏγ射线全身照射６Ｇｙ的大鼠和光烧伤背部皮肤３０％ＴＢＳＡⅢ度模型，动态地观察了放射损伤、烧伤及放烧复合伤大鼠心肌细胞膜β－肾上腺素能受体（βＡＲ）密度在伤后１，３，８，１６和２４小时的变化情况。结果表明，放射损伤、烧伤和放烧复合伤后心肌细胞膜βＡＲ的最大结合容量（Ｂｍａｘ）在伤后所观察的５个时相点皆有明显的下降。心肌细胞膜βＡＲ密度下降可能是引起放射损伤、烧伤和放烧复合伤后心肌功能受抑制的主要原因之一。本文作者对心肌细胞膜βＡＲ密度下降的原因进行了探讨。Rats were divided into three groups and subjected to total body irradiation of 6 Gy γ rays from a 60Co source, 30% total body surface area full tfickness burns,or both of them,respectively. The changes of β-adrenoceptor. concentration in myocardial membrane were observed on 1, 3.8, 16 and 24h after injury.It was found that Bmax was significantly decreased in all the three groups during 24h after injury. The value of KD increased only at 1h and 3h after radiation injury. The decrease of β-adrenoceptor concentration in rats may be one of the major reasons for cardiac dysfunction after radiation, burn and combined injuries, The reasons of decreasing β-adrenoceptor concentration are discussed.

关 键 词：放射损伤 烧伤 放烧复合伤 受体 心肌细胞膜 

分 类 号：R644[医药卫生—外科学] R818.02[医药卫生—临床医学]