乳腺癌中bag-1的表达及与腋窝淋巴结转移的关系  

Expression of bag-1 and its correlation with axillary lymph node metastasis in breast cancer.

作　　者：贠军[1] 易军[1] 王廷[1] 姚青[1] 王岭[1] 张聚良[1] 李晓军[1] 

机构地区：[1]第四军医大学西京医院血管内分泌外科,陕西西安710032

出　　处：《现代肿瘤医学》2006年第3期275-277,共3页Journal of Modern Oncology

摘　　要：目的探讨乳腺癌组织中bag-1的表达及其与肿瘤细胞增殖和腋窝淋巴结转移的关系。方法收集100例乳腺癌,其中有腋窝淋巴结转移的58例。采用免疫组化SABC法检测bag-1的表达情况。结果bag-1在乳腺癌组织中阳性表达率为85.0%;在I、II、III期的乳腺癌中bag-1阳性表达率分别为87.5%,82.4%,88.2%,三者无明显差异(P>0.05);有腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为89.6%,无腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为78.6%,无明显差异(P>0.05)。结论乳腺癌中bag-1高表达,其表达与肿瘤细胞增殖和腋窝淋巴结转移无关。Objective To investigate the expression of bag - 1 gene and its correlation with axillary lymph node metastasis in breast cancer. Methods Expression of bag - 1 in 100 cases of breast cancer （58 cases with axillary lymph node metastasis ） were detected by SABC immunohistochemistry. Results The positive rate of bag - 1 expression in breast cancer was 85.0%. The bag - 1 expression rate among pathologic grades Ⅰ、Ⅱ、Ⅲ were 87.5% ,82. 4% ,88.2% respectively, and no significant difference were observed （P 〉0.05）. The positive rates of bag- 1 expression between breast cancer with axillary lymph node metastasis and that without axillary lymph node metastasis were 89.6% ,78.6% respectively, and no significant difference was observed （P 〉0.05）. Conclusion There is an overexpression of bag - 1 in breast cancer and the expression is not related to axillary lymph node metastasis.

关 键 词：BAG-1 免疫组化 转移 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]