胰腺癌患者血清转化生长因子-α水平检测及手术前后对比研究  

Level of serum transforming growth factor-α and change before and after operation in patients with pancreatic cancer.

作　　者：梁启廉[1] 陈小东[1] 李建文[1] 王三明[1] 张英[1] 张远起[1] 康旭[1] 揭育丽 

机构地区：[1]广东医学院附属医院,广东湛江524001

出　　处：《现代肿瘤医学》2006年第3期308-310,共3页Journal of Modern Oncology

摘　　要：目的研究转化生长因子-α(TGF-α)在胰腺癌患者血清中的表达水平,探讨其与胰腺癌临床病理特征与预后的关系。方法应用放射免疫分析法(RIA法)检测65例胰腺癌患者的血清TGF-α水平,以30例正常人作为对照,并比较35例胰腺癌患者手术前后血清TGF-α水平。结果血清TGF-α与临床分期、细胞分化程度有关;与胰腺癌患者性别、年龄无关。胰腺癌患者血清TGF-α水平明显高于正常对照组(P<0.01);Ⅳ期胰腺癌血清TGF-α明显高于其它各期(P<0.01),Ⅲ期明显高于Ⅱ期(P<0.05),Ⅱ期明显高于Ⅰ期(P<0.01),低分化导管腺癌患者血清TGF-α水平显著高于中、高分化导管腺癌患者(P<0.05);胰腺癌患者根治性切除术后血清TGF-α水平明显低于术前(P<0.01)。结论检测血清TGF-α对评价胰腺癌疗效、病情监测及预后判断有一定的价值。Objective To investigate serum transforming growth factor-α（TGF-α） in patients with pancreatic cancer to explore their relationship with clinical pathological characters and prognosis. Methods The level of serum TGF -α was measured by radioimmunoassay （ RIA ） in 30 cases of normal control subject and 65 cases of patients with pancreatic cancer, compared with 35 patients with pancreatic cancer before and after operation. Results Serum TGF -α was correlated with clinical stage and histological grade, and not with sex and age, level of serum TGF -α was elevated in all subgroups of patients with pancreatic cancer compared to the controls （ P 〈0.01 ）, the serum TGF -α level in stage Ⅳ was higher than stage Ⅲ, Ⅱ and Ⅰ （ P 〈 0.01 ） , in stage Ⅲ it was higher than in stage Ⅱ （ P 〈 0. 05） ,and stage Ⅱ higher than stage Ⅰ （P 〈0.01 ） , higher in the poorly differentiated than the well differentiated and moderately differentiated （P 〈 0.05 ） ; The level of serum TGF -α was obviously reduced in patients with pancreatic cancer after operation （ P 〈 0.01 ）. Conclusion Determination of serum TGF -α may be useful in patients with pancreatic cancer for diagnosis and prognosis as well as in evaluating the efficacy of operation.

关 键 词：血清转化生长因子-α 胰腺癌 

分 类 号：R735.9[医药卫生—肿瘤]