具不良生活习惯者胃蛋白酶原C基因多态性的研究  

A study of polymorphism of pepsinogen C gene among the personswith bad life habit.

作　　者：陈亮[1] 黄煌[1] 刘晶[2] 

机构地区：[1]湘南学院医学基础课部,湖南郴州423000 [2]湘南学院化学与生命科学系,湖南郴州423000

出　　处：《现代肿瘤医学》2006年第3期318-319,共2页Journal of Modern Oncology

基　　金：湘南学院课题资助项目(项目编号04Y017)

摘　　要：目的通过调查具不良生活习惯如抽烟、喝酒者胃蛋白酶C基因多态性分布情况,研究生活习惯与胃癌病因之间的关系。方法采用PCR检测具不良生活习惯者中胃蛋白酶原C基因的多态性。结果既抽烟又喝酒者52人中,等位基因1出现频率比对照组高且差异有统计学意义(P<0.05)结论既抽烟又喝酒者是胃癌发病的高危险人群。Objective To study the relationship between the life habit and the cause of the stomach cancer , through investigation about polymorphism of pepsinogen C gene among the persons with bad life habit, such as smoking and drinking. Methods By means of PCR to detect polymorphism of pepsinogen C gene of the subjects. Results Allele Ⅰ showed higher frequency in those people （52 cases ） who were smoker and drinker than thai in the contrast group （X^2 = 5.58, P 〈 0.05 ）. Conclusion Those people who smoke and drink are more easily suffered from stomach cancer.

关 键 词：生活习惯 胃癌 胃蛋白酶原C基因 多态性 

分 类 号：R735.2[医药卫生—肿瘤]