乙型肝炎病毒X基因及HBx蛋白的研究进展  

Functional Progresses in X Gene of Hepatitis B Virus and Protein HBx

作　　者：汪琼[1] 董俊兴[1] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850

出　　处：《生物技术通讯》2006年第1期78-80,共3页Letters in Biotechnology

摘　　要：我国是乙型肝炎高发区,乙型肝炎病毒(HBV)X基因及其编码的多功能蛋白HBx是乙型肝炎病毒基因转录所必需的作用因子,在乙肝的致病过程中起到重要作用。HBx可直接或间接改变肝脏结构细胞的结构和功能,引发肝脏细胞的凋亡;具有广泛的非特异性反式激活作用,反式激活细胞内的某些癌基因或病毒基因,与乙型肝炎和肝细胞癌的发生关系十分密切。本文从多方面综述了X基因及HBx蛋白目前的研究进展,展现了X基因功能的多样性。There are many hepatitis B patients in our country. X gene and multifunctional X protein （HBx） translated by X gene are necessary for gene transcription of hepatitis B virus. It has an important role in HBV pathogenesis and possible carcinogenesis. HBx can change the structure and function of the liver cells directly or indirectly, induce apoptosis in liver cells, have a broad non-specific transactivation function, moderately stimulate transcription of many different oncogenes and viral transcription elements, and play important roles in the course of tumorigenesis. This review focused on progress in X gene and HBx, and showed us a muhifunction plot of X gene.

关 键 词：乙型肝炎病毒 X基因 HBX蛋白 反式激活 

分 类 号：R512.62[医药卫生—内科学] Q75[医药卫生—临床医学]