乳酸杆菌通过定植和提供免疫信号调节宿主免疫反应  

Lactobacillus Modulate Host Immune Response through Colonization and Provision of Immune Signals

作　　者：孙进[1] 施用晖[1] 乐国伟[1] 马西艺[1] 苏广伟[1] 

机构地区：[1]江南大学食品学院食品营养与安全研究所,江苏无锡214036

出　　处：《科技导报》2006年第2期43-46,共4页Science & Technology Review

基　　金：教育部博士点基金资助项目(20040295005)

摘　　要：提取了Lactobacillussp.的肽聚糖,用AffymetrixMOE430A基因芯片研究了肽聚糖对机体免疫细胞基因表达的影响。结果发现,乳酸杆菌肽聚糖可以刺激免疫细胞Th1型免疫反应相关基因的表达,可能激活TLR-NF-κB相关信号通路,同时,不同剂量的肽聚糖可能通过调节Tollip的表达,影响TLR-NF-κB信号通路的激活,从而调节细胞因子的表达。Peptidoglycan （PG） was prepared from Lactobacillus sp. Effects of Lactobacillus sp. PG on gene expression of mice immunocytes were studied by using Affymetrix MOE430A Genechip. PG was found inducing expression of molecules related to type 1 immune response. TLR-NF-κB signal pathway would be activated. The expression of Tollip, a negative regulator of TLR-NF-κB signal pathway was modulated by different doses of PG, which could lead to different expressions of different cytikons.

关 键 词：免疫反应 乳酸杆菌 信号调节 宿主 定植 免疫细胞 信号通路 NF-κB 肽聚糖 

分 类 号：R392.1[医药卫生—免疫学]