^(99)Tc^m-HL91SPECT/CT显像检测高血压脑出血乏氧组织的初步观察  

Detection of Brain Hypoxic Tissue in the Patients with Hypertensive Cerebral Hemorrhage Using ^(99)Tc^m HL91 SPECT/CT Imaging

作　　者：黎冠东[1] 黄斌豪[1] 李冰华[1] 黄焕章[1] 钟建新[1] 唐开雄[1] 陈学中[1] 赖穗翩[1] 

机构地区：[1]广东省江门市中心医院,江门529070

出　　处：《热带医学杂志》2006年第2期153-155,F0003,共4页Journal of Tropical Medicine

基　　金：广东省科技厅资助基金项目(No.2005B36001040)

摘　　要：目的探讨乏氧组织显像剂99Tcm-4,9-二氮-2,3,10,10-四甲基十二烷-2,11-二酮肟(HL91)SPECT/CT脑显像检测高血压脑出血出血灶周围乏氧组织的应用价值。方法22例高血压脑出血患者,和6例正常人均进行99Tcm-HL91SPECT脑显像,所有研究对象同时进行同机CT扫描。结果22例患者中18例阳性,阳性率为77.78%。4例阴性者分别是3例出血量<15ml的小量脑出血和1例出血量为23.5ml,起病43d行乏氧检查者。对照组6例均为阴性。乏氧区位于出血区周围,少量出现在血肿内,乏氧体积大小与出血量有正相关关系。结论99Tcm-HL91SPECT显像可较好地显示高血压脑出血病病灶周围的乏氧组织,乏氧体积与出血量有密切关系,可应用于指导临床治疗。Objective To investigate the detection of the brain hypoxic tissue surrounding the cerebral lesion in the patients with hypertensive cerebral hemorrhage using 99^Tc^m-4,9-diaza-2,3,10,10-tetramethydedecan-2,11-dione dioxime （HL91） SPECT/CT imaging. Method 22 patients with hypertensive cerebral hemorrhage and 5 normal controls underwent 99^Tc^m-HL91 SPECT imaging and CT simultaneously with the same machine. Results In 22 patients with hypertensive cerebral hemorrhage, 18 （77.78%） cases showed positive, 4 negative cases including 3 cases with the blood volume 〈15 ml, and 1 case with the blood volume of 23.5 ml at 43 d after the onset. All normal controls showed negative imaging. The brain hypoxic tissue was found around the margin of the hemorrhage, with small amounts occured in the blood area, and the volume was positively correlated with the blood volume. Conclusion 99^Tc^m-HL91 SPECT/CT imaging could detect the hypoxic tissue surrounding the cerebral hemorrhage. The hypoxic tissue volume are correlated with the blood volume. This imaging and scanning method can be used for clinical diagnosis.

关 键 词：脑出血 乏氧 单光子计算机断层扫描 HL91 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]