云南地区白细胞介素1基因型分布与幽门螺杆菌感染的关系  

The distribution characteristics of interleukin-1 genotype and its relationship with Helicobacter pylori in Yunnan region

作　　者：李丙生[1] 周曾芬[2] 刘功成[1] 李晓燕[2] 蒋海燕[2] 贾友兰[2] 

机构地区：[1]湖南郴州市第一人民医院消化内科,423000 [2]昆明医学院第一人民医院消化内科

出　　处：《中华检验医学杂志》2006年第2期111-113,共3页Chinese Journal of Laboratory Medicine

基　　金：云南教委基金资助项目(OZQY131)

摘　　要：目的探讨云南地区白细胞介素1(IL-1)基因型分布特点及其与幽门螺杆菌(HP)感染、定植密度间的关系。方法对符合研究标准的患者,进行HP感染及HP定植密度的评定;用PCR-RFLP检测外周血的IL-1B-511、IL-1B+3954、IL-1RN的基因型。结果IL-1B-511基因型中,C/C24例(17.3%)、C/T75例(54.0%)、T/T40例(28.8%);IL-1B+3954基因型中,C/C132例(95.0%)、C/T7例(5.0%)、无T/T;IL-1RN位点L/L与1/2基因型各占111例(79.9%)、27例(19.4%)、2/2基因型1例。IL-1B-511含T基因型是DU患者HP感染的易感因素,OR为6.1。在≥60岁亚组中,IL-1B-511含T基因型是HP定植密度程度的危险因素,OR为8.0。结论东西方非胃肿瘤患者人群IL-1基因型分布存在差异,为研究东西方人群HP感染相关临床结局类型差异的原因提供线索。IL-1B-511含T基因型与DU患者HP感染率高及与易形成重度HP感染相关。Objective To study the distrbuition characteristics of interleukin-1 genotype and the relation between interleukin-1 genotype and the infection and density of helicobacter pylori in Yunnan region. Methods The infection and density of helicobacter pylori were investigated from the gastric mucous membrane samples ; The genotypes of interleukin-1 beta-511 （ IL-1B^- 511 ）, interleukin-1 beta ＋ 3954 （ IL- 1 B^＋3954） , interleukin-1 receptor antibody （IL-1RN） from peripheral blood were determined by the polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results Among interleukin-1 beta-511 （IL-1B^-511 ） genotypes, There were C/C genotype 24 cases （ 17.3% ） ,C/T 75 cases （54.0%） ,T/T 40 cases （28.8%） ; among interleukin-1 beta ＋ 3954（ IL-1B^＋3954 ） genotypes, There were C/T genotype 7 cases （ 5. 0% ）, C/C genotype 132 cases （95.0%）, no T/T ; Interleukin-1 receptor antibody （IL-1RN） genotypes, There was 1/4 ,2/2 genotype each 1 case,1/1 110 cases （79.2%） ,1/2 27 cases （ 19.4% ）. IL-1 B^-511 ＊/T genotype is predisposing factor for helicobacter pylori infection, OR value is 6.1. In patients with age above 60 years old, IL-1 B^-511 ＊/T genotype is risk factor for helicobacter pylori density,OR value is 8.0. Conclusion There was difference in the clinical results related to helicobacter pylori-infection between people in east and in west. IL-1B^-511 ＊/T genotype was related to the extra high H. pylori detection rate in patients with DU, this genotype could easily result in severe infection of helicobacter pylori.

关 键 词：受体 白细胞介素1 基因 螺杆菌 幽门 云南 

分 类 号：R573[医药卫生—消化系统] R512.62[医药卫生—内科学]