草酸铂联合TNF腹腔内注射治疗胃肠道肿瘤所致腹水  

Effects of oxaliplatin combined with TNF by intraperitoneal perfusion for malignant ascites

作　　者：朱青山[1] 

机构地区：[1]安阳市人民医院肿瘤科,河南安阳455000

出　　处：《现代医药卫生》2006年第6期800-801,共2页Journal of Modern Medicine & Health

摘　　要：目的:观察草酸铂(L-OHP)联合新型重组人肿瘤坏死因子(NrhTNF)腹腔内注射治疗恶性腹水的临床疗效、不良反应、对生存质量的影响。方法:20例晚期胃肠道肿瘤所致恶性腹水患者,(L-OHP)联合NrhTNF腹腔内注射,每周1次,连续2周。结果:20例患者无CR,PR55%(11/20),SD35%(7/20)。主要不良反应为腹痛、发热、恶心,均较轻微。生活质量改善80%(16/20)。结论:(L-OHP)联合NrhTNF腹腔内注射治疗晚期胃肠道癌性腹水效果显著,不良反应轻微,可明显改善患者生存质量。Objective：To observe the clinical effects, side effects and influence on survival quality of oxaliplatin combined with new recombinant human tumor necrosis factor （NrhTNF） by intraperitoneal perfusion for malignant ascites. Methods：Twenty patients with malignant for malignant ascites. Methods：Twenty patients with malignant ascites caused by gastrointestinal tumor were treated with oxaliplatin combined with NrhTNF by intraperitoneal perfusion once a week for two weeks. Results：In twenty patients,there were no CR,but PR 55%（11/20）,SD 35%（7/20）. The major side effects were abdominal pain,fever and nausea,all of them were mild. The survival quality got improved in 80%（16/20） of patients. Conelusion：Intraperitoneal perfusion of oxaliplatin combined with NrhTNF had a good effect for malignant aseites caused by gastro-intestinal tumor with mild side effects, and could significantly improve the patients＇ survival quality.

关 键 词：恶性腹水 草酸铂 新型重组人肿瘤坏死因子(NrhTNF) 腹腔注射 

分 类 号：R73[医药卫生—肿瘤]