^(125)Ⅰ粒子气道内悬挂治疗癌性气道狭窄  

AIRWAY STRICTURE OF LUNG CANCER TREATED BY ENDOBRONCHIAL BRACHYTHERAPY WITH ^(125)Ⅰ SUSPENDED IN AIRWAY

作　　者：金普乐[1] 王平[1] 王敏[1] 

机构地区：[1]河北医科大学第四医院呼吸科,河北石家庄050011

出　　处：《实用临床医药杂志》2006年第1期65-67,共3页Journal of Clinical Medicine in Practice

基　　金：河北省卫生厅资助项目(04034)

摘　　要：目的探讨气道内悬挂125Ⅰ粒子治疗中心型肺癌引起的气道狭窄和肺不张的方法和疗效。方法采用环甲膜穿刺、置管、气道内悬挂125Ⅰ放射性微粒子方法,对中心型肺癌进行持续近距离放疗。治疗观察时间3个月。结果21例患者中,气道狭窄CR 5例、PR 10例、AC 4例、PD 2例,CR+PR 15(72%)。并发颈部瘘口炎性肉芽组织增生、喉部不适、导管刺激性咳嗽各3例,血WBC下降低于正常2例,导丝在颈部折断1例。结论经环甲膜穿刺,气道内悬挂125Ⅰ粒子对于治疗肺癌引起气道狭窄和肺不张的方法简便、安全和有效。Objective To evaluate the method and the efficacy of endobronchial brachytherapy to malignent airway stricture with ^125I implanted via cricothyroid membrane puncture and suspended in airway. Methods Central lung cancer had undergone endobronchial brathytherapy with ^125I implanted viacricothyroid membrane puncture and suspended in airway which was guided by X-rayor fiberoptic bronchoscopy. The treating time was three months. Results Of 21 cases, CR（airway stricture complete relief）, PR, AC, and PD were 5, 10, 4 and 2 respectively, CR ＋ PR was 15 （72 % ）. Complications such as inflammatory granuloma in neck, laryngeal malaise, irritating cough were just the same 3 patients; hypoleuko-cytosis and broken guidewire in neck were 2 and 1 respectively. Conclusion Endobronchial brachytherapy with ^125I implanted via cricothyroid membrane puncture and suspended in airway for malign airway stricture is simple, effective and safe.

关 键 词：^125I粒子 腔内放疗 肺癌 气道狭窄 

分 类 号：R734.2[医药卫生—肿瘤]