加入头形式和发光特性对激光诱导肿瘤间质热疗的影响  

Effect of Applicator Types and Emitting Characters on Laser-Induced Interstitial Thermotherapy

作　　者：江世臣[1] 张学学[1] 

机构地区：[1]清华大学热能工程系热科学与动力工程教育部重点实验室,北京100084

出　　处：《中国激光》2006年第3期428-432,共5页Chinese Journal of Lasers

基　　金：国家自然科学基金(50276032)资助项目

摘　　要：采用热疗过程中组织物性动态变化的光热模型,数值模拟了分别采用漫射光纤加入头和裸光纤加入头时的激光诱导肿瘤间质热疗(LITT)中热损伤体积的变化,并对实际漫射光纤加入头下发光强度不均匀的影响进行了分析。数值计算结果表明,通常情况下漫射光纤加入头产生的热损伤体积远大于裸光纤时的热损伤体积;裸光纤加入头产生的热损伤区域关于光纤端部不是球对称的,漫射光纤加入头产生的热损伤区域近似呈椭球形;漫射光纤产生的热损伤体积对加入头发光强度的非均匀性不太敏感。可见激光光纤加入头形式和发光特性对激光诱导肿瘤间质热疗具有重要的影响。To analyze the effects of applicator types and emitting characters on laser-induced interstitial thermotherapy （LITT）, based on an optlcal-thermal mathematical model considering the dynamic changes of physical properties during laser heating, the sizes and shapes of thermal damage regions for bare fiber tips and diffuse applicators were numerically calculated and compared. The effect of the un-uniform emitting radiation of practical diffuse applicator on the thermal damage region was also analyzed numerically. The numerical results showed that the thermal damage region with diffuse applicator was much larger than that with bare fiber for long time heating. The thermal damage region was not spherical symmetry about the fiber tip for bare fibers while approximately ellipsoidal for diffuse applicators. The numerical results also showed that the thermal damage region was not sensitive to the un-uniform emitting radiation of practical diffuse applicators. Applicator types and emitting characters significantly affected the thermal damage regions during laser-induced interstitial thermotherapy.

关 键 词：医用光学和生物技术 激光诱导肿瘤间质热疗 蒙特卡罗模拟 加入头 动态光热作用 

分 类 号：R730.57[医药卫生—肿瘤]