术前区域动脉灌注化疗对大肠癌患者血清血管内皮生长因子和内皮抑素的影响  

Effect of preoperative regional intra-arterial chemotherapy on serum vascular endothelial growth factor and endotatin levels in patients with colorectal carcinoma

作　　者：韩加刚[1] 李志霞[2] 安大立[2] 粱熙虹[3,4] 王烨 吴江平[2] 

机构地区：[1]首都医科大学附属北京朝阳医院普外科,100020 [2]首都医科大学附属北京同仁医院普外科 [3]首都医科大学附属北京同仁医院 [4]放射介入科 [5]北京博爱医院普外科

出　　处：《中华普通外科杂志》2006年第2期135-137,共3页Chinese Journal of General Surgery

摘　　要：目的研究术前区域动脉灌注化疗(PRAC)后大肠癌患者血清血管内皮生长因子 (s-VEGF)、血清内皮抑素(s-endostatin)的变化。方法以酶联免疫吸附试验(ELISA)法检测22例大肠癌患者手术前后s-VEGF和s-endostatin的水平。结果大肠癌患者化疗前s-VEGF、s-endostatin 水平与Dukes分期显著相关(P<0．01)。在根治性手术组患者中,化疗前s-VEGF、s-endostatin水平明显高于化疗后7 d、术后1 d和术后14 d(P<0．05)。姑息性手术组仅有化疗前s-endostatin水平明显高于术后1 d(P<0．05)。结论 PRAC可能通过抑制肿瘤血管生成而具有抗肿瘤作用;而化疗后 s-endostatin的水平下降,提示联合应用化疗药物和抗血管生成制剂可能获得更好的抗肿瘤效果。Objective To determine serum vascular endothelial growth factor （s-VEGF） and serum endostatin （s-endostatin） levels in patients with colorectal cancer after preoperative regional intraarterial chemotherapy （PRAC）. Methods Peripheral venous blood was sampled preoperatively and postoperatively, and was assayed for VEGF and endostatin by ELISA. Results Patients＇ preoperative level of s-VEGF and s-endostatin elevated significantly, which was in close correlation with Dukes＇ stage. The level of s-VEGF and s-endostatin before chemotherapy elevated significantly compared with that on day 7 after chemotherapy and on postoperational day l and 14 after operation. In patients undergoing palliative resection, only the level of s-endostatin before chemotherapy was significantly higher than that on day 1 after operation. Conclusions PRAC, inhibiting angiogenesis, is of antitumor effect, the decrease of s-endostatin after chemotherapy may suggest the combination of chemotherapy and antiangiogenesis for a better antitumor effect.

关 键 词：结肠肿瘤 药物疗法 内皮生长因子 内皮抑素 

分 类 号：R735.34[医药卫生—肿瘤]