Causal role of Helicobacter pylori infection in gastric cancer  

作　　者：Takafumi Ando Yasuyuki Goto Osamu Maeda Osamu Watanabe Kazuhiro Ishiguro Hidemi Goto 

机构地区：[1]Department of Gastroenterology,Nagoya University Graduate School of Medicine,Japan

出　　处：《World Journal of Gastroenterology》2006年第2期181-186,共6页世界胃肠病学杂志（英文版）

摘　　要：Gastric cancer is the second most frequent cancer in the world, accounting for a large proportion of all cancer cases in Asia, Latin America, and some countries in Europe. Helicobacter pylori（H pylori） is regarded as playing a specific role in the development of atrophic gastritis, which represents the most recognized pathway in multistep intestinal-type gastric carcinogenesis. Recent studies suggest that a combination of host genetic factors, bacterial virulence factors, and environmental and lifestyle factors determine the severity of gastric damage and the eventual clinical outcome of H pylori infection. The seminal discovery of Hpylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication.胃的癌症是在世界，为在亚洲的所有癌症盒子的一个大比例的财务，拉丁美洲，和在欧洲的一些国家上的第二很经常的癌症。Helicobacter pylori (H pylori ) 被认为是在萎缩性胃炎的发展起一个特定的作用，它多代表最公认的小径在走肠类型的胃的致癌作用。最近的研究建议那联合招待基因因素，细菌的毒力因素，并且环境并且生活方式因素决定胃的损坏和 H pylori 感染的最终的临床的结果的严厉。胃的癌症的领先的原因应该导致有效根除策略的 H pylori 的精液的发现。胃的癌症的预防要求更好屏蔽的策略为根除识别候选人。

关 键 词：Gastric cancer Host genetic factors HPYLORI Bacterial virulence factors 

分 类 号：R735.2[医药卫生—肿瘤]