Management and treatment of lactose malabsorption  

作　　者：Massimo Montalto Valentina Curigliano Luca Santoro Monica Vastola Giovanni Cammarota Raffaele Manna Antonio Gasbarrini Giovanni Gasbarrini 

机构地区：[1]Department of Internal Medicine,Catholic University,Rome,Italy

出　　处：《World Journal of Gastroenterology》2006年第2期187-191,共5页世界胃肠病学杂志（英文版）

摘　　要：Lactose malabsorption is a very common condition characterized by intestinal lactase deficiency. Primary lactose malabsorption is an inherited deficit present in the majority of the world＇s population, while secondary hypolactasia can be the consequence of an intestinal disease. The presence of malabsorbed lactose in the colonic lumen causes gastrointestinal symptoms. The condition is known as lactose intolerance. In patients with lactase nonpersistence, treatment should be considered exclusively if intolerance symptoms are present. In the absence of guidelines, the common therapeutic approach tends to exclude milk and dairy products from the diet. However, this strategy may have serious nutritional disadvantages. Several studies have been carried out to find alternative approaches, such as exogenous β-galactosidase, yogurt and probiotics for their bacterial lactase activity, pharmacological and non pharmacological strategies that can prolong contact time between enzyme and substrate delaying gastrointestinal transit time, and chronic lactose ingestion to enhance colonic adaptation. In this review the usefulness of these approaches is discussed and a therapeutic management with a flow chart is proposed.乳糖吸收不良是肠的乳糖酶缺乏描绘的一个很普通的条件。主要乳糖吸收不良是在世界的人口的多数在场的继承赤字，当第二等的 hypolactasia 能是肠的疾病的后果时。在结肠的腔的 malabsorbed 乳糖的存在引起胃肠的症状。条件作为乳糖不耐被知道。在有乳糖酶的病人非坚持，如果不耐症状是在场的，治疗应该只被考虑。当指南不在时，普通治疗学的途径趋于从食谱排除牛奶和奶店产品。然而，这策略可以有严肃的营养的劣势。几研究被执行了发现其他的途径，例如为他们的细菌的乳糖酶活动的外长的贝它牛乳糖，酸乳酪和职业人员生命学，药理学、非药理学能延长的策略联系在推迟胃肠的运输时间，和长期的乳糖摄取提高结肠的改编的酶和底层之间的时间。在这评论，这些途径的实用性被讨论，有一份流动图表的一个治疗学的管理被建议。

关 键 词：LACTOSE MALABSORPTION INTOLERANCE THERAPY 

分 类 号：R57[医药卫生—消化系统]